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http://dx.doi.org/10.3746/jkfn.2004.33.4.633

Cytotoxic Effect of Inonotus obliquus Composition in HCT-15 Human Colon Cancer Cells and AGS Gastric Cancer Cells  

차재영 (동아대학교 응용생명공학부)
전병삼 (경상대학교 의과대학 미생물학교실)
문재철 ((주)홍재그린)
유지현 (동아대학교 응용생명공학부)
조영수 (동아대학교 응용생명공학부)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.4, 2004 , pp. 633-640 More about this Journal
Abstract
This study was performed to investigate the cytotoxic effect of the water-extract from Chaga mushroom (Inonotus obliquus) compositions containing powdered green tea in HCT-15 human colon carcinoma, AGS human gastric carcinoma and NIH3T3 mouse normal fibroblast cells using viable cell count and MTT assay. The water-extract from Chaga mushroom compositions induced inhibitory effects on proliferation of HCT-15 and AGS cells in the MTT assay and viable cell count. However, mouse normal NIH3T3 cells were exhibited 80% survival under the same condition. Chaga mushroom compositions showed highly antiproliferative effect in human cancer cell line HCT-15 and AGS, but not in mouse normal cell line NIH3T3. These results suggest that Chaga mushroom (Inonotus obliquus) compositions containing powdered green tea are the candidate for chemoprevention in colon and gastric cancer.
Keywords
Inonotus obliquus; HCT-15 human colon carcinoma; AGS human gastric carcinoma; NIH3T3 mouse normal fibroblast cell;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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