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http://dx.doi.org/10.3746/jkfn.2004.33.3.469

The Effects of the Arabinoxylane and the Polysaccharide Peptide (PSP) on the Antiallergy, Anticancer  

배만종 (대구한의대학교 한방식품과학부)
이성태 (순천대학교 생물학)
채수연 (순천대학교 생물학)
신성해 (순천대학교 생물학)
권상호 (안동과학대학 식품과학)
박미현 (이롬라이)
송미경 (이롬라이)
황성주 (이롬라이프)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.3, 2004 , pp. 469-474 More about this Journal
Abstract
The objective of the current study was to determine the effects of arabinoxylane and polysaccharide peptide (PSP) on the immune cell functions. Both arabinoxylane and PSP increased plaque forming cell (10-15%) and rosette forming cell (10-30%) formation. Stimulation of macrophage with PSP (18%) and arabinoxylane (22%) resulted in increased phagocytic effects. Both arabinoxylane and PSP induced the tumor suppressive effect in mice injected sarcoma-180 cell intracutaneously. When the mice injected intraperitoneal cavity with sarcoma 180 cells, survival ratio was increased in the mice fed on arabinoxylane and PSP. The ratio of PCA was slightly decreased in the mice fed on PSP, especially fed on arabinoxylane than in the control mice. The concentrations of blood histamine were slightly decreased in the mice fed on arabinoxylane and PSP. These results suggest that the capacity of arabinoxylane and PSP seems to act as a potent immunomodulator causing augmentation of immune cell activity, and with the absence of notable side-effects, arabinoxylane and PSP could be used as a biological response modifier having possible therapeutic effects against immunological disorders.
Keywords
arabinoxylane, polysaccharide peptide (PSP), sarcoma-180, histamine;
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