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http://dx.doi.org/10.3746/jkfn.2004.33.1.078

Effect of an Oriental Herbal Composition, Jang Baek Union (JBU), on Alcohol-Induced Hangover and CCl4-Induced Liver Injury in Rats  

양동식 (한국한의학연구원 의료연구부)
홍성길 (한국한의학연구원 의료연구부)
최선미 (한국한의학연구원 의료연구부)
김복남 (장백산간신약물연구소)
성현제 (세명대학교 한의과대학)
윤우식 (한국한의학연구원 의료연구부)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.1, 2004 , pp. 78-82 More about this Journal
Abstract
Effects of the extract of oriental herbal composition, Jang Baek Union (JBU), on hangover and liver function were studied in rats. To investigate anti-hangover effect, alcohol concentration and acetaldehyde concentration of blood were measured after oral ethanol treatment. Blood alcohol concentration was significantly reduced by pre-treatment of JBU extract. The effect of JBU extract on the blood acetaldehyde concentration was more significant than commercial product used as a positive control. To investigate hepato-protective effect, serum GOT and GPT levels and histological changes of liver tissue were analyzed in $CCl_4$-treated rats. JBU extract adminstration significantly inhibited the increase of serum GPT and GOT levels induced by $CCl_4$-treatment. Moreover, histological injuries of liver tissue such as fatty changes and sinusoidal leukocytosis were inhibited by JBU extract.
Keywords
ethanol; acetaldehyde; hangover; hepato-protective; $CCl_4$;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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