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http://dx.doi.org/10.3746/jkfn.2004.33.1.034

A Study of Medicinal Plants for Applications in Functional Foods 1. Effects of Schizandrae fructus on the Regional Cerebral Blood Flow and Blood Pressure in Rats  

박성혜 (원광대학교 한의학전문대학원 한약자원개발학과)
한종현 (원광대학교 한의학전문대학원 한약자원개발학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.1, 2004 , pp. 34-40 More about this Journal
Abstract
The purpose of this study was to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) in rats, following the intravenous injection of Schizandrae fructus water extract. The measurement was continually monitored by laser-doppler flowmeter and pressure tranducer in anesthetized adult Sprague-Dawley rats for 2 hours to 2 hours and a half through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as followed. Schizandrae fructus increased the changes of rCBF in rats significantly. The rCBF of Schizandrae fructus did not change by pretreated propranolol, atropine, L-NNA and indomethacin. But the rCBF of Schizandrae fructus was increased by pretreated methylene blue. Schizandrae fructus decreased the changes of BP, significantly. The BP of Schizandrae fructus did not change by pretreated propranolol, atropine, L-NNA and indomethacin. But the BP of Schizandrae fructus was decreased by pretreated methylene blue. There results indicated that Schizandrae fructus can increase the rCBF and decrease the BP, that is related to guanylyl cyclase activity.
Keywords
regional cerebral blood flow; blood pressure; Schizandrae fructus; food material; functional food;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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