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http://dx.doi.org/10.3746/jkfn.2004.33.10.1589

Antioxidative and Antitumor Activities of Crude Polysaccharide Fraction from P leurotus eryngii  

Kim, Jae-Yong (경북대학교 식품공학과)
Kang, Hye-In (순천대학교 식품영양학과)
Park, Kyung-Uk (순천대학교 식품영양학과)
Moon, Kwang-Deog (경북대학교 식품공학과)
Lee, Sang-Dae (경남 농업기술원)
Cho, Sook-Hyun (경남 농업기술원)
Wee, Jae-Joon (KT&G 중앙연구원)
Kyung, Jong-Soo (KT&G 중앙연구원)
Song, Yong-Beom (KT&G 중앙연구원)
Seo, Kwon-Il (순천대학교 식품영양학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.10, 2004 , pp. 1589-1593 More about this Journal
Abstract
The aims of this study were to investigate the antioxidative and antitumor effects of crude polysaccharide fraction from Pleurtus eryngii (CPPE). CPPE inhibited autoxidation of linoleic acid at 1,000 $\mu$g/mL concentration, and the inhibitory rates of lipid peroxidation in rat liver microsome were 5.28, 9.40, and 32.5% at 10, 100, and 1,000 $\mu$g/mL concentrations, respectively. After treatment with CPPE for 72 hours, the inhibitory rates against MCF-7, A549 and AGS cell lines showed 42.3, 33.4 and 26.7% at concentration of 1,000 $\mu$g/mL, respectively. Results of CPPE treatment at 100 and 300 mg/kg/day for 7 days in sarcoma-180 bearing-mice showed survival rates of 70 and 90%, respectively. Body weights of mice treated with CPPE were significantly decreased when compared with the control.
Keywords
Pleurotus eryngii; polysaccharide; antioxidative effect; antitumor effect;
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Times Cited By KSCI : 3  (Citation Analysis)
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