Browse > Article
http://dx.doi.org/10.3746/jkfn.2003.32.7.971

Screening of Prolyl Endopeptidase Inhibition from Korean Natural Foods  

이성현 (농촌진흥청 농업과학기술원 농촌생활연구소)
박홍주 (농촌진흥청 농업과학기술원 농촌생활연구소)
조용식 (농촌진흥청 농업과학기술원 농촌생활연구소)
정인경 (농촌진흥청 농업과학기술원 농촌생활연구소)
송경식 (경북대학교 농화학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.7, 2003 , pp. 971-975 More about this Journal
Abstract
This study was performed to find natural foods with high anti-dementia effects from natural plant resources which have been used for mental health. We screened inhibitors of prolyl endopeptidase which could be implicated in the processing of Alzheimer's disease, the principal part of dementia. One hundred natural foods were examined for prolyl endopeptidase inhibitors. Out of them, methanol extract of Acorns and Raspberry inhibited more than 90% of prolyl endopeptidase activity at 40 ppm. Also, methanol extract of Walnut inhibited 73% of prolyl endopeptidase activity at the same concentration. Therefore, the result suggests that these natural foods may have the potential to be used for preventing and treating dementia like Alzheimer disease.
Keywords
natural foods; prolyl endopeptidase; dementia; alzheimerPs disease;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. 1991. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563: 311-314.   DOI   ScienceOn
2 Kato A, Fukunari A, Tabira T, Shimizu T, Arahata K, Sugita HD. 1997. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senesceneaccelerated mouse. J Pharmacol Exp Therap 283: 328-335.
3 Schneider JS, Giardiniere M, Morain P. 2002. Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys. Neuropsychopharmacology 26: 176-182.   DOI   ScienceOn
4 Lee KH, Lee HJ, Park HI. 1997. Screening of prolyl endopeptidase inhibitors from natural products. Yakhak Hoeji 41: 153-160.   과학기술학회마을
5 Kim S. 1999. Purification of prolyl endopeptidase from Mountan Cortex. MS Thesis. Kyungpook National University, Daegu. p 4.
6 Aoyagi T, Nagai M, Ogawa K, Gojima F, Okada M, Ikeda T, Hamada M, Takeuchi T. 1991. Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogens MH 534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiotics 44: 949-955.   DOI
7 UN. 1998. "World Population Prospects".
8 Katzman R. 1986. Alzheimer's Disease. N Eng J Med 314:964-973.   DOI   ScienceOn
9 Ishiura S, Nishikawa T, Tsukahara T, Momoi T, Ito H, Suzuki K, Sugita H. 1990. Distribution of Alzheimer's disease amyloid A4-generating enzyme in rat brain tissues. Neurosci Lett 115: 329-334.   DOI   ScienceOn
10 Aoyagi T, Wada T, Nagai M, Kojima F, Harada S, Tkeuchi T, Takahashi H, Hirokawa K, Tsumita T. 1990. Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease. Experientia 46: 94-97.   DOI
11 Hardy JA. 1997. The presenility and Alzheimer's disease. TINS 20: 154-158.
12 Lee HJ, Kim JS, Heo GY, Lee KB, Rhee IK, Song KS. 1999. Inhibitory activities of basidiomycetes on prolyl endopeptidase, acetylcholine esterase and coagulation. J Korean Soc Agric Chem Biotechnol 42: 336-343.   과학기술학회마을
13 Kimura K, Kawguchi N, Yoshihama M, Kawanishi G. 1990. Staurosporine, a prolyl endopeptidase inhibitor. Agric Biol Chem 54: 3021-3022.   DOI   ScienceOn
14 Selkoe DJ. 1990. Deciphering Alzheimer's Disease: the amyloid precursor protein yields new clues. Science 248: 1058-1060.
15 Kim SI, Song KS. 2000. 1, 2, 3, 4, 6-pentagalloyl-$\beta$-Dglucopyranose, A prolyl endopeptidase inhibitor from moutan cortex. J Korean Soc Agric Chem Biotechnol 43: 158-161.   과학기술학회마을
16 Katsuo T, Masahiko S, Yohko I, Takako F, Kazuhiro O, Atsuhiro U. 1997. A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behavioural Brain Research 83: 147-151.   DOI   ScienceOn
17 Kimura K, Kanou F, Takahashi H, Esumi Y, Uramoto M, Yoshihama M. 1997b. Propeptin, a new inhibitor of prolyl endopeptidase produced by microbispora. I. Fermentation, isolation and biological properties. J Antibiotics 50: 373-378.   DOI   ScienceOn
18 Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. 1985. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Natl Acad Sci 82: 4245-4249.   DOI   ScienceOn
19 Yoshimoto T, Kado K, Matsubara F, Koriyama N, Kaneto H, Tsuru D. 1987. Specific inhibitors of prolyl endopeptidase and their anti-amnesic effect. J Pharmacobio Dyn 10: 730-735.   DOI
20 Khanom F, Kayahara H, Tadasa K. 2000. Superoxide-scavenging and prolyl endopeptidase inhibitory activities of Bangladeshi indigenous medicinal plants. Biosci Biotech Biochem 64: 837-40.   DOI   ScienceOn
21 Lee HJ, Kim JH, Lee JH. 1999. Inhibitory activities of sea weeds on prolyl endopeptidase, tyrosinase and coagulation. Kor J Pharmacogn 30: 231-237.   과학기술학회마을
22 Kimura K, Kanou F, Yoshihama M, Koshino H, Uramoto M. 1997a. SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. J Antibiotics 50: 291-296.   DOI   ScienceOn
23 Cho EJ. 1999. Characteristics and vision for the elderly.Ministry of Health and Welfare Form 29: 6-16.
24 Kim JH, Kim SI, Song KS. 2001. Prolyl endopeptidase inhibitors from green tea. Arch Pharm Res 24: 292-296.   과학기술학회마을   DOI   ScienceOn
25 Bakker AV, Jung S, Spencer RW, Vinick FJ, Faraci WS. 1990. Slow tight-binding of prolyl endopepetidase by benzyloxycarbonyl-prolyl-prolinal. Biochem J 274: 559-562.
26 Selkoe DJ. 1991. The molecular pathology of Alzheimer's disease. Neuron 6: 487-498.   DOI   ScienceOn
27 Toda S, Obi Y, Numata K, Hamagishi Y, Tomita K, Komiyama N, Kotake C, Furumai T, Oki T. 1992. Eurystatins A and B, new prolyl endopeptidase inhibitors. I. Taxonomy, production, isolation and biological activities. J Antibiotics 45: 1573-1579.   DOI
28 Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. 1997. Polyozellin, a new inhibitor of prolyl endopeptidase from polyozellus multiflex. J Antibiotics 50: 773-777.   DOI   ScienceOn