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http://dx.doi.org/10.3746/jkfn.2003.32.7.1114

The Effects of Sedum sarmentosum Bunge on Collagen Content of Connective Tissues in Ovariectomized Rats  

김미향 (신라대학교 식품영양학과 및 마린바이오 기능성소재산업화지원센터)
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Journal of the Korean Society of Food Science and Nutrition / v.32, no.7, 2003 , pp. 1114-1119 More about this Journal
Abstract
The aim of this study was to evaluate the effects of Sedum sarmentosum Bunge (SS) on the collagen content of the connective tissues in ovariectomized rats. From day 2 until day 37 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with SS at 50 mg/kg BW/day (OVX-SS50), 100 mg/kg bw/day (OVX-SS100) and 200 mg/kg bw/day (OVX-SS200), and an ethyl ether fraction of SS at 10 mg/kg bw/day (OVX-EE) and an ethyl acetate fraction of SS at 10 mg/kg bw/day (OVX-EA). The SS ethanol extracts and SS fractions were orally administrated 1 mL per day. The OVX rats were significantly heavier than the sham-operated rats at all time points, but supplementation with the SS extracts tended to gain weight less than OVX-control. Supplementation with the SS extracts prevented a decrease in the collagen level in bone and cartilage tissues. These results are consistent with the conclusions based on the estrogenic activities of SS. Therefore, it may be used to possibly improve the quality of life in menopausal women.
Keywords
Sedum sarmentosum Bunge; collagen; connective tissues; ovariectomized rats;
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