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http://dx.doi.org/10.3746/jkfn.2003.32.7.1076

Effects of Formula (JR-22) Maybe Containing Traditional Herbs on Maximal Exercise Performance and Antioxidant Meterials in Murine Model  

홍성길 (한국한의학연구원 의료연구부)
양동식 (한국한의학연구원 의료연구부)
강봉주 (한국한의학연구원 의료연구부)
이홍석 (㈜바이오랩 기술연구소)
윤유식 (한국한의학연구원 의료연구부)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.7, 2003 , pp. 1076-1081 More about this Journal
Abstract
The effects of dietary supplementation of JR-22, formula containing distilled extracts of traditional herbs on maximal exercise performance and endurance were evaluated in mouse and rat model. In acute forced swimming test with 4%∼8% of the body weight attached to the tail, it was shown that dietary JR-22 supplementation increased endurance in exercise performance. There was no change of blood lactic acid, ammonia, inorganic phosphorous ion and creatine kinase activity, however ATP concentration in muscle was increased by JR-22 supplementation. Also, insulin-like growth factor-l (IGF-1) concentration in blood was significantly increased by JR-22 supplementation. In addition, the oxidative damage induced by exercise was reduced by JR-22 supplementation. In these results, we suggested that JR-22 supplementation enhanced maximal endurance exercise performance by the mechanism of increasing ATP and IGF-1 concentration and reducing oxidative damage.
Keywords
endurance; IGF-1; fatigue index; traditional herb; natural product;
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1 Rossiter HB, Cannerll ER, Jakeman PM. 1996. The effects of oral creatine supplementation on the 1000-m performance of competitive rowers. J Sports Sci 14: 175-179.   DOI   ScienceOn
2 Carr CJ. 1986. Natural plants products that enhance performance and endurance. In Enhancers of performance and endurance. Carr CJ, Joki E, eds. Lawrence erlbaum Associates, NJ.
3 Singleton JR, Feldman EL. 2001. IGF-1 in muscle metabolism and myotherapies. Neuribiol Dis 8: 451-454.
4 Nilsson A, Isgaard J, Lindahl A, Dahlstrom A, Skottner A, Isaksson GP. 1986. Regulation by growth hormon of number of chondrocytes containing IGF-1 in rat growth palte. Science 223: 571-574.   DOI   ScienceOn
5 Millar NC, Homsher E. 1990. The effects of phosphate and calcium on force generation in glycerinated rabbit skeletal muscle fibers. J Biol Chem 265: 20234-20240.
6 Murklund S, Marlund G. 1974. Involvement of the superoxide anion radical in the antioxidation of pyrogallol and a convenient assay for superoxide dismutase. J Biochem 47: 469-474.
7 Paik IY, Kim JK, Chun YS, Oho HJ. 1997. Verifying the validity of fatigue elements changes following absolute exercise intensities. Kor J Physical Edu 36: 218-223.
8 Vina J, Gimeno A, Sastre J, Terada LS. 2000. Mechanism of free radical production in exhaustive exercise in humans and rats: role of xanthine oxidase and protection by allopurinol. IUBMB Life 49: 539-544.   DOI   ScienceOn
9 Butterweck V, Jurgenliemk G, Nahrstedt A, Winterhoff H. 2000. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta. Med 66: 3-6.   DOI   ScienceOn
10 Gottlieb C. 1987. Adenosine triphosphate in human semen: A study on condition for a bioluminescence assay. Feril Steril 47: 992-999.
11 Roith DL. 1997. Insulin-like growth factors. New Eng J Med 336: 633-640.   DOI   ScienceOn
12 Laron Z. 2001. Insulin-like growth factor 1 (IGF-1): a growth hormone. J Clin Pathol Mol Pathol 54: 311-316.   DOI   ScienceOn
13 Walker JW, Moss RL. 1991. Thin filament modulation of cross-bridge transition measured by photogeneration of Pi in skeletal muscle fibers. Biophys J 59: 418-423.
14 Cappola AR, Bandeen-Toche K, Wand GS, Volpato S, Fried LP. 2001. Association of IGF-1 levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 86: 4139-4146.   DOI   ScienceOn
15 Baranov AI. 1982. Medicinal use of ginseng and rleated plants in the soviet Union. J Ethnopharm 5: 339-353.
16 Park IY, Park TS, Oh SW, Woo JH, Jin HE, Park HR. 2002. The effects of Eleutherococcus senticosus on human fatigue factors and oxidant-antioxidant system during maximal and submaximal exercise. Korea J Phys Edu 41: 305-315.
17 Aebi H. 1974. Catalase. In Method of enzyme analysis. Bergmeyer HU, ed. Academic Press, New York.
18 Song Y, Han DS, Oh SW, Paik IY, Park T. 2002. Effect of dietary supplement of Eleutherococcus senticosus, taurine and carnitine on endurance exercise performance in rats. Korea J Nutr 35: 825-833.   과학기술학회마을
19 Yagi K. 1976. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15: 212-216.   DOI   ScienceOn
20 Poldidori MC, Mecoccis P, Cherubini A, Senin U. 2000. Physical activity and oxidative stress during hypertensive rats. Am J Hypertension 21: 154-157.
21 Wei R, Cao Z. 1992. Effects of Radix astragali and Radix ginseng in enhancing the metabolism of human myocardial cells in vitro. Chung Kuo Chung Yao Tsa Chih 17: 173-175.