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http://dx.doi.org/10.3746/jkfn.2003.32.7.1071

Antioxidant and Genotoxic Inhibition Activity of Ethanol Extract from the Inonotus obliquus  

함승시 (강원대학교 식품생명공학부)
오상화 (강원대학교 식품생명공학부)
김영균 (국민대학교 임산공학과)
신광순 (경기대학교 식품생명공학과)
장현유 (한국국립농업대학 버섯학과)
정국훈 (두산그룹 생명공학연구조합)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.7, 2003 , pp. 1071-1075 More about this Journal
Abstract
This study was performed to observe the antioxidative and genotoxic effect of the fractions from Inonotus obliquus using DPPH test and micronucleus assay. Stepwise fractionation of the ethanol extract from Inonotus obliquus was done by using hexane, chloroform, ethyl acetate, butanol and water to obtain effective fraction. Each fraction was tested in 1.5 ${\times}$ 10$^{-4}$ DPPH. Among six fractions, the ethyl acetate fraction showed the highest electron donating activities (46.5 $\mu\textrm{g}$/mL). The results on genotoxic effects on insoluble fractions and most of fractions showed cytotoxic effects more than 90% activity. These results suggest that some components contained in the Inonotus obliquus showed such activities and much more studies have to perform.
Keywords
antioxidant; genotoxicity; Inonotus obliquus;
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