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http://dx.doi.org/10.3746/jkfn.2003.32.6.906

Effects of Saengshik Supplementation on Health Improvement in Diet-Induced Hypercholesterolemic Rats  

강상모 (건국대학교 미생물공학과)
심지영 (건국대학교 미생물공학과)
황성주 ((주)이롬라이프 생명과학연구원)
홍성길 ((주)이롬라이프 생명과학연구원)
장혜은 ((주)이롬라이프 생명과학연구원)
박미현 ((주)이롬라이프 생명과학연구원)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.6, 2003 , pp. 906-912 More about this Journal
Abstract
The study was conducted to investigate the effect of Saengshik supplementation on lipid metabolism in rats fed high cholesterol diets. Male Spraque-Dawley rats were administrated 1% cholesterol to induce hypercholesterolemia and were fed on diet containing Saengshik (30%, w/w). Serum and liver lipid profiles and fecal bile acids excretion were examined after 7 weeks of experimental diet. The feeding of diet containing 30% Saengshik significantly decreased total cholesterol (TC) contents in liver and plasma. Since cholesterol was balanced by entero-hepatic circulation through bile acid synthesis and reabsorption, inhibition of bile acid re-uptake in intestine decreases total cholesterol in liver and blood. In this point, significant increament of fecal bile acid excretion in Shaengshik group decreased TC and improved hypercholesterolemia. Also plasma high density lipoprotein-cholesterol (HDL-C) decreasing risk for coronary heart disease in Saengshik supplemented group was significantly higher than control group, whereas low-density lipoprotein-cholesterol (LDL-C) accumulation in arterial vessel wall was significantly lower than control group. In this result, we supposed that supplementation of Saengshik, uncooked natural food, may improve hypercholesterolemia through increment of cholesterol excretion.
Keywords
Saengshik; hypercholesterolemia; lipid metabolism; atherogenic index;
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