Browse > Article
http://dx.doi.org/10.3746/jkfn.2003.32.4.614

Studies on a New Alimentotherapy for Diabetic Patients  

라정찬 (서울대학교 수의과대학 수의학과 공중보건학교실)
배진희 (RNL 생명과학㈜)
박형근 (RNL 생명과학㈜)
강경선 (서울대학교 수의과대학 수의학과 공중보건학교실)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.4, 2003 , pp. 614-620 More about this Journal
Abstract
Mulberry, Morifolium leaves and fruits, Lycii fructus, and Panax ginseng have been known to maintain normal blood sugar levels in folk medicine. Here we investigated the effects of coated rice (Sodangmi$^{TM}$) with these herb extracts to diabetes mellitus patients. Alloxan-induced diabetic mice (80 mg/kg bw, i.v.) separated into 4 groups. 2 groups received the mixed extracts of these plants (Sodans Extract$^{TM}$) orally everyday for 4 weeks. Positive control received Alloxan except Sodans Extract$^{TM}$. Negative control received neither Alloxan nor Sodang Extract$^{TM}$. Blood sugar levels, volume of water consumed, body weights of each group were measured and compared. Blood sugar levels in the Alloxan and Sodang Extract$^{TM}$-received groups got close to normal levels on 4th week after starting the experiments. Volume of water consumed also showed similar pattern. Blood sugar levels in positive control remained high through the experimental periods. Body weights in positive control remained low, but those in the extracts-received groups recovered to normal levels. The clinical trials for both of healthy volunteers and diabetes mellitus patients also showed Sodangmi$^{TM}$ could control blood sugar level. The blood sugar level decreased since 3rd week after starting to receive Sodangmi$^{TM}$, and the difference between the blood sugar level before and after the meal was decreased significantly by receiving Sodangmi$^{TM}$. From these results, we suggest that the functional rice with herb extracts could be used as a new alimentotherapy for diabetes mellitus patients.llitus patients.
Keywords
alimentotherapy; diabetes; Mori folium; Lycii fructus; Panax ginseng; Inonotus obliquus;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Korea Food & Drug Administration notices. 2001. Standard and test method of pharmaceuticals. 2nd edition. Yakup Shinmoon Inc. p 766.
2 Chung SH. 1993. The searching method of antidiabetic. In Methods in new drugs development from traditional medicinal meterials. Natural Products Research Institute, Seoul National University. p 68-77.
3 Korean Diabetes Association. 1992. Recent concept of diabetes mellitus. In Diabetology. Korea Medical. Chapter 1, p 1-3.
4 Purusotam B, Shigetoshi K, Satoshi T, Mineo S, Tsuneo N. 1993. Two new 2-arylbenzofuran derivatves from hypoglycemic activity-bearing fractions of morus insignis. Chem Pharm Bull 41: 1238-1243.   DOI   ScienceOn
5 Rhee IJ, Lee DM. 1994. The effect of antipolydipsia oriental proscriptions on experimental diabetic rats-Cheongsimyeonjaeum, Kamijowiseunki-tang, Kikukjihwang-tang. YAKHAK HOEJI 38: 555-561.
6 Kim MS, Choue RW, Chung SH, Koo SJ. 1988. Blood glucose lowering effects of Mulberry leaves and silkworm extracts on mice fed with high-carbohydrate diet. Korean Nutrition Soc 31: 117-125.   과학기술학회마을
7 Sheo HJ, Jun SJ, Lee MY. 1986. Effects of Lycii fructurs extract on experimentally induced liver damage and allozan diavetes in rabbits. J Korean Soc Food Nutr 15: 136-143.
8 Korean Diabetes Association. 1992. Oral hypoglycemic. In Diabetology. Korea Medical. Chapter 31, p 277-293.
9 Ahn DG. 1993. A Folk Remedy, 1st Ed. Eul Gi Moon Sha Sa, Seoul. p 205-211.
10 Taniguch S, Asano N, Tomino F, Miwa I. 1998. Potentiation of glucose-induced insulin secretion by fagomine, a pseudosugar isolated form Mulberry leaves. Horm Metab Res 30: 679-684.   DOI   ScienceOn
11 Lee JS, Choi MH, Chung SH. 1995. Blood glucose-lowering effects of Mori folium. Yakhak Hoeji 39: 367-372   과학기술학회마을
12 Sung GB. 1998. Recent mulberry research trend and direction for the improvement. Korean J Seric Sci 40: 180-184
13 Ryu KS, Lee HS, Chung SH, Kang PD. 1997. An activity of lowering blood-glucose levels according to preparative conditions of silkworm powder. Korean J Seric Sci 39: 79-85.   과학기술학회마을
14 Kahn YH. 1994. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43: 1066-1084.   DOI
15 Hong JH, Park MR, Rhee SJ. 2002. Effects of YK-209 Mulberry leaves on HMG-CoA reductase and lipid composition of liver in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 31: 826-833.   과학기술학회마을   DOI   ScienceOn
16 Atkinson MA, Maclaren NK. 1990. What causes diabetes?. Scientific America 52 (suppl. 1): 2-49.
17 Kim NJ, Youn WG, Hong ND. 1994. Pharmacological effects of Lycium chinensis. Kor J Pharmacogn 25: 264-271.   과학기술학회마을
18 Park SY, Cho KH. 1994. Effects of Commelina communis L. on the blood glucose level in alloxan induced diabetic rat and the biochemical properties of glucose-6-phosphate dehydrogenase from the rat at livers. Kor J Pharmacogn 25: 238-248.
19 Yen GC, Wu SC, Duh PD. 1996. Extraction and identification of anti-oxidant components form the leaves of mulberry (Morus alba L.). J Biol Chem 261: 12879-12882.
20 Kim JW, Ryu KS. Chromatography A, In press.
21 Nam MS, Kim KR, Cho JH, Lee KM, Park HY, Lee EJ, Lim SK, Lee HC, Huh KB. 1994. A study on the folk remedies by the questionaries in Korean diabetic patients. Diabetes 18: 242-381.
22 Ahn DG. 1993. A Folk Remedy. 1st ed. Dae Won Sa, Seoul. p 85-89.
23 Maeng YS, Park HK, Kwon TB. 1990. Analysis of rutin contents in Buckwheat and Buckwheat foods. Korean J Food Sci Technol 22: 732-737.   과학기술학회마을
24 Choue YA. 1993. Diabetes Mellitus Diary. 7th ed. Woo Li Pulic, Seoul. p 38-257.
25 Yoshikuni Y. 1988. Inhibition of intestinal ${\alpha}-glucosidase$ activity and postprandial hyper-glycemia by moranoine and its N-alkylated deribates. Agric Biol Chem 52: 121-128.   DOI
26 Choi HJ, Kim NJ, Kim DH. 2000. Inhibitory effect of GE974 isolated from Gyrophora esculenta on ${\alpha}-glucosidase$. Kor J Pharmacogn 31: 196-202.   과학기술학회마을
27 Markham KR. 1989. Flavones, flavonols and their glycosides. Methods in Plant Biochemistry 1: 197-235.
28 全國韓醫科大學 本草學敎授共編著. 1991. 本草學 第17章 補益藥: 桑 子. 永林社. p 598.
29 Heo GY. 1991. Popular food, harmfutness food. A folk Oriental medicine remedy for subject. A Monthly Diabetes Magazine 5: 25-31.
30 Cha HS. 1997. Change in physicochemical properties of korean mume (Jananese apricot, Prunus mume Sieb. et Zucc) ftuits during maturation and storage. MS Thesis. Kyunghee University.
31 Kim OK, Lee EB. 1992. The screening of plants for hypoglycemic action in normal and alloxan-induced hyperglycemic rats. Kor J Pharmacogn 23: 117-119.   과학기술학회마을
32 Kim KS, Shim SH, Jeong GH, Cheong CS, Ko KH, Park JH, Huh H, Lee BJ, Kim BK. 1998. Anti-diabetic activity of constituents of Lycii Fructus. J Appl Pharmacol 6: 378-382.
33 Kim OK, Lee EB. 1993. Antihyperglycemic constituent of Aralia elata root bark (I)-Antihyperglycemic action of the MeOH extract and fractions. Kor J Pharmacogn 24: 213-218.   과학기술학회마을