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http://dx.doi.org/10.3746/jkfn.2002.31.1.136

Enhancement of Anticarcinogenic Effect by Combination of Sedum sarmentosum Bunge with Platycodon grandiflorum A. Extracts  

박윤자 (신라대학교 식품영양학과)
김미향 (신라대학교 식품영양학과)
배송자 (신라대학교 식품영양학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.31, no.1, 2002 , pp. 136-142 More about this Journal
Abstract
Anticarcinogen is one of the major strategies for cancer control. It is well established that dietary factors play an important role in modulating the development of certain types of human cancer. We investiagted the anticarcinogenic effects of Sedum sarmentosum Bunge (SS) with Platycodon grandiflorum A. extracts on HepG2, HeLa and MCF-7 cell lines. By the MTT assay, among the five partition layers of methanol extract of SS (SSM), the ethylether partition layer of SS (SSMEE) showed the strongest cytotoxic effects on all cell lines. We also investigated the synergistic effect of the combination of SS and PG extracts on growth inhibition of the HepG2, HeLa and MCF-7 cell lines compared to the effects of five partition layers of SSM. Combination of SS and PG extracts significantly increased cytotoxic effects on all cell lines. Therefore, we were able to conclude that ethylether partition layer, SSMEE might have potentially useful cytotoxic materials on all the human cancer cells which we used. And we could suggest that the combination of SS with PG enhanced the anticarcinogenic effect on HepG2, HeLa and MCF-7 cell lines. We also determined QR activity of partition layers of SSM, among them, SSMEE on HepG2 cells showed the highest QR activity, 3.21 as control value of 1.0.
Keywords
cytotoxicity; quinone reductase; Sedum sarmentosum Bunge (SS); cancer cell lines;
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1 Prochaska, H.J. and Santamaria, A.B. : Direct measurement of NAD(P)H : Quinone reductase from cells cultured in microtiter wells : A screening assay for anticarcinogenic enzyme inducers. Anal. Biochem., 169, 328-336 (1988)   DOI   ScienceOn
2 Gould, M.N. : Cancer chemoprevention and therapy by monoterpenes. Environ. Health Perspec., 105, 977-979 (1997)   DOI   ScienceOn
3 Cooper, G.H. : Elements of Human Cancer. Jones and Bantlett publishers, Inc., Boston, p.31 (1992)
4 Dewys, W.D., Malone, W.F., Butrum, R. and Setili, M.A.: Clinical trials in cancer prevention cancer. Cancer Res., 60, 650-656 (1987)
5 Lee, K.Y., Lee,Y.C., Park, Y.S., Yoon, K.H. and Kim, B.S.: A study of relation between dietary vitamin A intake and serum vitamin A levels and cancer risk in Korea. Korean J. Nutr., 18, 301-311 (1995)   과학기술학회마을
6 Murakami, A., Ohigashi, H. and Soshimizu, K. : Anti tumor promotion with food phytochemicals : A stategy for cancer chemoprevention. Biosci. Biotech. Biochem., 60, 1-9 (1996)   DOI   ScienceOn
7 Han, E.J., Roh, S.B. and Bae, S.J. : Effects of quinone reductase induction and cytotoxicity of the Angelica radix extracts. J. Korean Soc. Food Sci. Nutr., 29, 147-152 (2000)   과학기술학회마을
8 Choi, S.Y., Cheigh, M.J., Lee, J.J., Kim, H.J., Hong, S.S., Chung, K.S. and Lee, B.K. : Growth suppression effect of traditional fermented soybean paste (doenjang) on the various tumor cells. J. Korean Soc. Food Sci. Nutr., 28, 458-463 (1999)   과학기술학회마을
9 Benson, A., Hunkeler, M.J. and Talaly, P. : Increase of NAD (P)H : quinone reductase by dietary antioxidants; possible role in pretection against carcinogenesis and toxicity. Proc. Natl. Acad. USA, 77, 5216-5220 (1980)   DOI   ScienceOn
10 Prostera, T., Holtzclaw, W.D., Zhang, Y. and Talaly, P. : Chemical and detoxify carcinogens. Proc. Natl. Sci. USA, 90, 2965-2969 (1993)   DOI   ScienceOn
11 Kang, H.J. : Screening for anticarcinogenic enzyme inducer(s) from roasted and defatted perilla. M.S. Thesis, Pusan National University (1998)
12 Park, H.J. : Induction of quinone reductase and its regulatory mechanism at the transcriptional level by Scutellaria baicalensis. Ph.D. Dissertation, Yonsei University (1998)
13 Doll, R. and Peto, R. : The causes of cancer quantitative estimate of avoidable risks of cancer in the united states today. J. Natl. Cancer Inst., 66, 1191-1197 (1981)
14 Weinstein, I.B. : Cancer prevention : Recent progress and future opportunities. Cancer Res., 51, 5080s-5085s (1991)
15 Shim, S.M., Choi, S.W. and Bae, S.J. : Effects of Punica grantum L. Fractions on quinone reductase induction and growth inhibition on several cancer cells. J. Korean Soc.Food Sci. Nutr., 30, 80-85 (2001)   과학기술학회마을
16 Katiyar, S.K. and Mukhtar, H. : Tea in chemoprevention of cancer : Epidemiologic and experimental studies (review). Intl. J. Oncol., 8, 221-238 (1996)
17 Calls, L.M. and Sullivan, P.D. : Screening of antioxidants and other compounds for antimutagenic properties towards benzo(a)pyrene-induced mutagenicity in strain Ta98 of salmonella typhimurium. Mutat. Res., 101, 99-105 (1982)   DOI
18 Leu, T.H. : Reaction of food, nutrition and cancer. J. Korean Food Sci. Nutr., 14, 305-311 (1985)
19 Carmichael, J., De Graff, W.G., Gazder, A.F., Minna, J.D. and Mitchell, J.B. : Evalution of a tetrazolium based semiautomated colorimetric assay : assessment of chemosensitivity testing. Cancer Res., 47, 936-942 (1987)
20 Cheng, G.C., Lee, J.Y., Kim, D.C., Suh, S.O. and Hwang, W.I. : Inhibitory effect of Salvia miltiorrhiza extract on growth of some cancer cells. J. Korean Soc. Food Sci. Nutr., 29, 726-731 (2000)   과학기술학회마을
21 Messina, M. and Barnes, S. : The role of soy products in reducing risk of cancer. J. Natl. Cancer Inst., 83, 541-546 (1991)   DOI
22 Kim, H.J., Han, J., Yang, E.J., Lee, K.R. and Lee, I.S. : hemoprevention effect of Polyozellus nultiplex, a wild and edible mushroom. J. Korean Soc. Food Sci. Nutr., 29, 161-167 (2000)   과학기술학회마을
23 Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. : Food derived mutagens and carcinogens. Cancer Res. (suppl), 52, 2092-2098 (1992)
24 Hasler, C.M. : Functional foods : Their role in disease prevention and health promotion. Food Technol., 52, 63-70 (1998)
25 Choi, O.J. : Component and using of medical plants. Ilwoulsegak, Seoul, p.312-313 (1999)
26 Michael, C.A., Dominic, A.S., Anne, M., Miriam, L.H., Maciej, J.C., Donald, L.F., Betty, J.A., Joseph, G.M., Robert, H.S. and Michael, R.B. : Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res., 48, 589-601 (1988)
27 Clinton, S.K. : Lycopene: Chemistry, biology and implications for human health and disease. Nutr. Rev., 56, 35-51 (1998)   DOI