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http://dx.doi.org/10.13103/JFHS.2015.30.2.202

Protective Effects of Capsosiphon fulvescens and Pheophorbide a on Streptozotocin-induced Oxidative Stress in Testicular  

Son, Won-rak (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Nam, Mi-Hyun (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Han, Ah-Ram (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Pyo, Min-Cheol (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Kim, Se-Wook (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Jung, Hye-Lim (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Lee, Hwa (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Kim, Ji-Yeon (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Lee, Kwang-Won (Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University)
Publication Information
Journal of Food Hygiene and Safety / v.30, no.2, 2015 , pp. 202-209 More about this Journal
Abstract
We investigated the effect of Capsosiphon fulvescens (CFE) and pheophorbide a (PhA) contained in CFE on oxidative stress regarded as a factor for diabetic complication. Streptozotocin (STZ), known as an oxidative stress inducer, was intraperitoneal injected for causing diabetes. After 7 days, CFE (4 and 20 mg/kg body weight) and PhA (0.2 mg/kg body weight) were treated once a day for 9 weeks. After the sacrifice, testis tissues were collected for the experiments. We confirmed that the treatment with CFE and PhA in diabetic animals not only decreased level of lipid peroxidation and serum nitric oxide compared with the diabetes group, but also the activities of glutathione peroxidase and glutathione-S-transferase were restored remarkably. Furthermore the activity of antioxidant enzymes, catalase and superoxide dismutase, were significantly recovered. With these results, our study suggest that CFE containing PhA may prevent seminal glands damages induced by oxidative stress in diabetic condition.
Keywords
Capsosiphon fulvescens; pheoporbide a; testis dysfunction; oxidative stress; antioxidant enzymes;
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