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http://dx.doi.org/10.13103/JFHS.2014.29.3.248

Effect of Methanol Extract of Dryopteris Crassirhizoma in Human Oral Cancer Cells  

Jang, Boonsil (Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Oh, Se-Jun (Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Shin, Ji-Ae (Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Lee, Hang-Eun (Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Jeon, Jae-Gyu (Department of Preventive Dentistry, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Cho, Sung-Dae (Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University)
Publication Information
Journal of Food Hygiene and Safety / v.29, no.3, 2014 , pp. 248-251 More about this Journal
Abstract
Dryopteris crassirhizoma is one of the naturally occurring substance wood ferns and is known for having anti-inflammatory, antiviral and anthelmintic activities. However, there is less report about its anticancer effect in human cancer cell lines. In the present study, the effect of methanol extract of dryopteris crassirhizoma (MEDC) on apoptosis in human oral cancer cell lines (MC3 and HN22 cells) was investigated. MEDC inhibited cell viability and induced apoptosis. MEDC significantly increased Bak and truncated Bid proteins in MC3 cells and elevated only truncated Bid compared to the control while other Bcl-2 family proteins were not altered. MEDC has anticancer activity by inducing apoptotic cell death through the regulation of either Bak or Bid. These findings suggest that its extract possibly may be used for treating oral cancer.
Keywords
Dryopteris crassirhizoma; Apoptosis; Oral cancer; Bak; Bid;
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