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http://dx.doi.org/10.13103/JFHS.2012.27.3.306

Increase of Liver Organ Weight in B6C3F1 Mice Fed with High dose Stevioside for 14 Days  

Lee, Hye-Young (Biotoxtech Co., Ltd., Ochang Scientific and Industrial Complex)
Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University)
Bang, In-Seok (Hoseo University)
Park, Cheol-Beom (Hoseo University)
Publication Information
Journal of Food Hygiene and Safety / v.27, no.3, 2012 , pp. 306-311 More about this Journal
Abstract
Stevioside, a natural sweeteners presently used in various kinds of food and food products in Korea, was evaluated for its toxicity potential in the 14 day feeding study using B6C3F1 mice. Stevioside was added to the diet at different concentrations of 0.31, 0.62, 1.25, 2.5 and 5%, and was administered for 14 consecutive days. An increase of liver organ weight in male mice was observed. No diet-related differences were noted in clinical signs, food consumption, and gross and histopatholgical evaluation. Based on these results, we concluded that the concentration of 5% in the diet was a suitable maximum tolerable dose of stevioside for a 90 day study in mice.
Keywords
Stevioside; mice; sweetener; chronic study;
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