1 |
Gupta, A. K., Cerniglia, G. J., Mick, R., Ahmed, M. S., Bakanauskas, V. J., Muschel, R. J., and McKenna, W. G. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int. J. Radiat. Oncol. Biol. Phys., 56, 846-853 (2003).
DOI
ScienceOn
|
2 |
Li, B., Yuan, M., Kim, I. A., Chang, C. M., Bernhard, E. J., and Shu, H. K. Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/Akt pathway and promotes radioresistance in cells of astrocytic origin. Oncogene, 23, 4594-4602 (2004).
DOI
ScienceOn
|
3 |
Xiong, Y., Hannon, G. J., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. p21 is a universal inhibitor of cyclin kinases. Nature, 366, 701-704 (1993).
DOI
ScienceOn
|
4 |
Gottschalk, A. R., Doan, A., Nakamura, J. L., Stokoe, D., and Haas-Kogan, D. A. Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. Int. J. Radiat. Oncol. Biol. Phys., 63, 1221-1227 (2005).
DOI
ScienceOn
|
5 |
Grana TM, Rusyn EV, Zhou H, Sartor CI, Cox AD. Ras mediates radioresistance through both phosphatidylinositol-3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal regulated kinase kinase-independent signaling pathways. Cancer Res, 62, 4142-4150 (2002).
|
6 |
Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases and downstream signaling pathways in the control of cell growth and survival. Front Biosci, 7, 376-389 (2002).
DOI
|
7 |
Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses. Radiat Res, 153, 245-257 (2000).
DOI
ScienceOn
|
8 |
Gupta AK, Bakanauskas VJ, Cerniglia GJ, et al. The Ras radiation resistance pathway. Cancer Res, 61, 4278-4282 (2001).
|
9 |
Devlin, T.M.: In Textbook of Biochemistry with clinical correlations, 6th ed. (2006).
|
10 |
Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816 (1993).
DOI
ScienceOn
|
11 |
Gupta, A. K., McKenna, W. G., Weber, C. N., Feldman, M. D., Goldsmith, J. D., Mick, R., Machtay, M., Rosenthal, D. I., Bakanauskas, V. J., Cerniglia, G. J., Bernhard, E. J., Weber, R. S., and Muschel, R. J. Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction. Clin. Cancer Res., 8, 885-892 (2002).
|
12 |
Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331 (1997).
DOI
ScienceOn
|
13 |
Merritt, A. J. et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res, 54, 614-617 (1994).
|
14 |
Baker SJ. PTEN Enters the Nuclear Age. Cell, 128, 25-28 (2007).
DOI
ScienceOn
|
15 |
Garcia et al. A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis. The EMBO journal, 25, 4740-4751 (2006).
DOI
ScienceOn
|
16 |
Edwards, E., Geng, L., Tan, J., Onishko, H., Donnelly, E., and Hallahan, D. E. E. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res., 62, 4671-4677 (2002).
|
17 |
Kim, I. A., Bae, S. S., Fernandes, A., Wu, J., Muschel, R. J., McKenna, W. G., Birnbaum, M. J., and Bernhard, E. J. Selective inhibition of Ras, Phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res, 65, 7902-7910 (2005).
|
18 |
Lee, C. M., Fuhrman, C. B., Planelles, V., Peltier, M. R., Gaffney, D. K., Soisson, A. P., Dodson, M. K., Tolley, H. D., Green, C. L., and Zempolich, K. A. Phosphatidylinositol 3-kinase inhibition by LY204002 radiosensitizes human cervical cancer cell lines. Clin. Cancer Res, 12, 250-256 (2006).
DOI
ScienceOn
|
19 |
Nakamura, J. L., Karlsson, A., Arvold, N. D., Gottschalk, A. R., Pieper, R. O., Stokoe, D., and Haas-Kogan, D. A. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J. Neuro-oncol, 71, 215-222 (2005).
DOI
ScienceOn
|