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Antimutagenic Study on Acanthopanax Koreanum Nakai  

Cho, Myung-Chan (Dept. of Herbal Medicinal Pharmacology, Daegu Haany University)
Hong, Chang-Eui (Dept. of Pharmacy, Yeungnam University)
Lyu, Su-Yun (Dept. of Herbal Medicinal Pharmacology, Daegu Haany University)
Publication Information
Journal of Food Hygiene and Safety / v.25, no.3, 2010 , pp. 215-219 More about this Journal
Abstract
This study was undertaken to investigate the mutagenicity and antimutagenicity of Acanthopanax koreanum Nakai. Antimutagenic study on extract of A. koreanum was studied using the test with Salmonella typhimurium TA100, TA98. And mutagenicity study was studied using the test with S. typhimurium TA100, TA98, TA1535, TA1537 and Escherichia coli WP2 uvr A. A. koreanum was negative in Ames test with S. typhimurium and E. coli with or without S-9 mixture. Test substances of $5000\;{\mu}g/{\mu}l$, $2500\;{\mu}g/{\mu}l$ and $600\;{\mu}g/{\mu}l$ of A. koreanum extracts were chosen via toxicity test. Ames test was performed on positive control group, experimental group and negative control group in the presence of the metabolic activation system and metabolic non-activation system. As a result, there was no coherent increase and reverse mutation in all concentrations. Therefore, A. koreanum does not cause reverse mutation. In addition, A. koreanum showed strong antimutagenic activities in S. typhimurim TA100 and TA98. In conclusion, A. koreanum root may be an excellent antimutagenic agent.
Keywords
Antimutagenic; Acanthopanax koreanum; Salmonella typhimurium; Ames test;
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Times Cited By KSCI : 5  (Citation Analysis)
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