Browse > Article

A study on the Establishment of Korean PTWI for Cadmium Based on The Epidemiological Data  

Choi, Chan-Woong (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Moon, Jin-Hyun (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Park, Hyoung-Su (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Ryeom, Tai-Kyung (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Lee, Kwang-Ho (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Lee, Hyo-Min (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Publication Information
Journal of Food Hygiene and Safety / v.24, no.4, 2009 , pp. 378-384 More about this Journal
Abstract
There are differences of Cadmium (Cd) urinary concentration which is considered as indicator of renal tubular dysfunction in other countries, so we have reviewed domestic epidemiological data and suggested Korean health based guidance value (HBGV) for Cd to improve an efficiency of risk management. We decided to apply the WHO calculation model which considered the relationship between dietary intake and Cd concentration in urine sample. It is determined that Cd concentration 2.5 ug/g creatinine in urine as the prevalence of renal tubular dysfunction based on epidemiological data, because there is no renal tubular dysfunction and injury/lesion such as proteinuria at the concentration of 11.63 ug/g creatinine which is the highest Cd concentration in urine from the domestic epidemiological data. It is identified that the ratio between the Cd dietary consumption (8.3~10.4 ug/day) and Cd urinary concentration (0.38 ug/g creatinine) in Korean adult who predicting never been exposed to Cd are 21.8~27.3 and then it is applied to the corresponding model suggested by WHO. Also it is applied that 10% of bioavailability and 50% of excretion rate of absorbed to body (the ratio is 24) were assumed. The estimate of daily Cd consumption level which begins tubular dysfunction is 1 ug/kg bw/day, so we suggest the Korean provisional tolerable weekly intake (PTWI) as 7 ug/kg bw/week.
Keywords
cadmium; health based guidance value; provisional tolerable weekly intake;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Nordberg, G., Jin, T., Bernard, A., Fierens, S., Buchet, J.-P., Ye, T., Kong, Q. & Wang, H., Low bone density and renal dysfunction following environmental cadmium exposure in China, Ambio, 31, 478-481 (2002)   PUBMED
2 Horiguchi, H., Oguma, E., Sasaki, S., Miyamoto, K., Ikeda, Y., Machida, M. & Kayama, F., Environmental exposure to cadmium at a level insufficient to induce renal tubular dysfunction does not affect bone density among female Japanese farmers, Environ. Res. (2004)   PUBMED
3 WHO, Evaluation of certain food additives and contaminants, 61-69 (2001).
4 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(충주) (2007)
5 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(포항) (2007)
6 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(광양) (2008)
7 Aoshima, K., Fan, J., Cai, Y., Katoh, T., Teranishi, H. & Kasuya, M., Assessment of bone metabolism in cadmiuminduced renal tubular dysfunction by measurements of biochemical markers, Toxicol. Let., 136, 183-192 (2003)   DOI   ScienceOn
8 KFDA, unpublished data (2007)
9 ATSDR, Toxicological profile for cadmium (2008)
10 Shibutani, M., Mitsumori, K., Niho, N., Satoh, S., Hiratsuka, H., Satoh, M., Sumiyoshi, M., Nishijima, M., Katsuki, Y., Suzuki, J., Nakagawa, J. & Ando, M., Assessment of renal toxicity by analysis of regeneration of tubular epithelium in rats given low-dose cadmium chloride or cadmium-polluted rice for 22 months, Arch. Toxicol., 74, 571-577 (2000)   DOI   ScienceOn
11 환경부, 대기환경연보 (2008)
12 KFDA, unpublished data (2005)
13 USEPA, A Review of the reference dose and reference concentration process (2002)
14 Honda, R., Tsuritani, I., Noborisaka, Y., Suzuki, H., Ishizaki, M. & Yamada, Y., Urinary cadmium excretion is correlated with calcaneal bone mass in Japanese women living in an urban area, Environ. Res., 91, 63-70 (2003)   DOI   ScienceOn
15 KFDA, 알루미늄의 TDI 평가 (2007)
16 환경부, 환경통계연감 (2008)
17 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(포항) (2008)
18 KFDA, 한국인 대표식품 중 오염물질 섭취량 및 위해도평가 (2007)
19 WHO, Principles and methods for the risk assessment of chemicals in food (2008)
20 KFDA, Diethylhexyl phthalate(DEHP)의 TDI 제안 및 다이옥신 TDI 재평가 연구 (2006)
21 환경부, 2차 국민 인체내 유해물질 실태 조사 (2008)
22 WHO, GEMS/Food Regional Diets(WHO/FSF/FOS/98.3), GMS/Food Programme (1998)
23 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(시화반월) (2008)
24 Whelton, B.D., Peterson, D.P., Moretti, E.S., Dare, H. & Bhattacharyya, M.H., Skeletal changes in multiparous, nulliparous and ovariectomized mice fed either a nutrient-sufficient or -deficient diet containing cadmium. Toxicol., 119, 103-121 (1997)   DOI   ScienceOn
25 환경부, 지역주민 환경오염 노출수준 및 생체시료 모니터링(강릉) (2007)
26 USEPA, Toxicological review: cadmium and compounds, Integrated risk information system (1999)