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Selenium arrest G1/S phase of cell cycle in LNCaP human prostate cancer cells  

Nam, Jeong-Seok (Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
Jung, Ji-Youn (Department of Companion and Laboratory Animal Science, Kongju National University)
Publication Information
Journal of Food Hygiene and Safety / v.24, no.3, 2009 , pp. 267-272 More about this Journal
Abstract
The trace element nutrient selenium discharges its well-known nutritional anti-tumor activity. Converging data from epidemiological, ecological and clinical studies have shown that selenium can decrease the risk for some types of human cancers, especially those of the prostate, lung, and colon. Mechanistic studies have indicated that selenium has many desirable attributes of chemoprevention targeting cancer cells through DNA single strand breaks, the induction of reactive oxygen species. However, there is no reports about the relationship between methylseleninic acid (MSeA), one of methylselenol metabolites and cell cycle arrest in LNCaP human prostate cancer cells. Our data showed that MSeA arrested G1/S pahse of cell cycle arrest and inhibited DNA synthesis in LNCaP cells and those cellular events by MSeA were due to the induction ofp27 protein which is a well-known cyclin-dependent kinase inhibitor. Taken together, cell cycle arrest occurred by MSeA may contribute to the growth-inhibition of prostate cancer cells.
Keywords
selenium; Methylseleninic acid (MSeA); cell cycle arrest; prostate cancer;
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Times Cited By KSCI : 2  (Citation Analysis)
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