Browse > Article

Diallyl Disulfide (DADS) Induces Upregulation of PTEN in Human Leukemia Cells  

Chung, Weon-Kuu (Department of Radiation Oncology, Konyang University Medical School)
Lee, Byoung-Kil (Department of Radiation Oncology, Konyang University Medical School)
Lee, Young-Rae (Department of Radiation Oncology, Chonbuk National University Medical School)
Park, Jin-Ny (Division of Hematology/Oncology, Gachon University Medical Center)
Kwon, Hyoung-Chul (Department of Radiation Oncology, Chonbuk National University Medical School)
Publication Information
Journal of Food Hygiene and Safety / v.24, no.1, 2009 , pp. 38-45 More about this Journal
Abstract
The differentiation of leukemia cells into mature cells is a major target of the human leukemia therapy. As differentiated leukemia cells lose their proliferative and tumor-forming abilities, differentiation inducers may be useful for the treatment of leukemia. In this study, the experiments were designed to determine whether diallyl disulfide (DADS) regulates expressions of tumor suppressor protein PTEN (phosphatase and tension homologue) in HL60 cells. DADS causes upregulation of PTEN in a time- and dose-dependent manner, which was correlated with decrease of phospho-Akt level. These results suggest that DADS induces upregulation of PTEN in human leukemia cells. These results suggest that DADS may be a useful anticancer agent for management of human leukemia.
Keywords
diallyl disulfide(DADS); PTEN (phosphatase and tension homologue); human leukemia;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Bisemi R, Cipriani F, Cocco P, Giacosa A, et aI., A casecontrol study of gastric cancer and diet in Italy. Int J. Cancer. 1989, 44(4):611-6   DOI   PUBMED
2 KwonKB, YooSJ,RyuDG, YangJY,RhoHW,KimJS,Park JW, Kim HR, and Park RH, Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem. Phannacol. 2002, 63(1):41-7   DOI   ScienceOn
3 Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C, Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels,but not associated with p27 and cyclin D 1 expression, in primary epithelial ovarian carcinomas. Am. J. Pathol. 2001, 158(6):2097-106   DOI   PUBMED   ScienceOn
4 Seminario MC, Precht P, Wersto RP, Gorospe M, Wange RL, PTEN expression in PTEN-nullieukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene. 2003, 22(50):8195-204   DOI   ScienceOn
5 Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, StokoeD, Yung WK, Mills GB, Steck PA, Adenoviral transgene expression ofMMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res. 1998, 58(23):5285-90   PUBMED
6 Lee YR, Yu HN, Noh EM, Kim JS, Song EK, Han MK, Kim BS, Lee SH, Park J., Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. Int. J. Hematol 2007, 85(3):231-7   DOI   ScienceOn
7 Collins SJ, Bodner A, Ting R, Gallo RC, Induction ofmorphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells. Proc. Natl. Acad. Sci. U. S. A. 1978, 75(5):2458-62   DOI   ScienceOn
8 Mangelsdorf DJ, Koeffier HP, Donaldson CA, Pike JW, Haussler MR, 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60):receptor-mediated maturation to macrophage-like cells. J. Cell BioI. 1984, 98(2):391-8   DOI   ScienceOn
9 Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z, Antiproliferative autoantigen CDAI transcriptionally up-regulates p21(Wafl/Cipl) by activating p53 and MEKlERK1I2 MAPK pathways. J. BioI. Chem. 2007, 282(16): 11722-31   DOI   ScienceOn
10 Shen YR, Zhang L, Gan Y, Wang X, Wang J, LeMaire SA, Coselli JS, Wang XL, Up-regulation of PTEN (phosphatase and tens in homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. J. BioI. Chem. 2006,281(12):7727-36   DOI   ScienceOn
11 Chandrasekar B, Valente AJ, Freeman GL, Mahimainathan L, Mummidi S, Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NFkappaB- dependent PTEN activation. Biochem. Biophys. Res. Commun. 2006, 339(3):956-63   DOI   ScienceOn
12 Hisatake J, O'Kelly J, Uskokovic MR, Tomoyasu S, and Koeffier HP, Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood. 2001, 97(8):2427-33   DOI   ScienceOn
13 Zhang W, Wu N, Li Z, Wang L, Jin J, Zha XL, PPAR gamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404. Cancer BioI. Ther. 2006, 5(8):1008-14   DOI   ScienceOn
14 Ling H, Zhang LY, Su Q, Song Y, Luo ZY, Zhou XT, Zeng X, He J, Tan H, Yuan JP, Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cellline MGC803. Cell Mol. BioI. Lett. 2006, 11(3):408-23   DOI   ScienceOn
15 Lee YR, Shim HJ, Yu HN, Song EK, Park J, Kwon KB, Park JW, Rho HW, Park BH, Han MK, Kim JS. Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells. Leuk. Res. 2005, 29(4):401-5. 22   DOI   ScienceOn
16 Weng LP, Gimm 0, Kum JB, Smith WM, Zhou XP, Wynford- Thomas D, Leone G, Eng C, Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death .. Hum. Mol. Genet. 2001, 10(3):251-8   DOI   ScienceOn
17 Milner JA, Diet and cancer: facts and controversies. Nutr. Cancer. 2006, 56(2):216-24   DOI   PUBMED   ScienceOn
18 Witcher M, Shiu HY, Guo Q, Miller WH, Jr, Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells. Blood 2004, 104:3335-3342   DOI   ScienceOn
19 Yuan JP, Wang GH, Ling H, Su Q, Yang YR, Song Y, Tang RJ, Liu Y, Huang C, Diallyl disulfide-induced G21M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways. World J. Gastroenterol. 2004, 10(18):2731-4   PUBMED
20 Lee KS, Park SJ, Hwang PH, Yi HK, Song CH, Chai OH, Kim JS, Lee MK, Lee YC, PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. FASEB. J. 2005,19(8):1033-5   PUBMED
21 Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C, PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum. Mol. Genet. 1999, 8(2):185-93   DOI   ScienceOn
22 Aggarwal BB, Shishodia S, Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71(10):1397-421   DOI   ScienceOn
23 Vivanco I, Sawyers CL, The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2002, 2(7):489-501   DOI   ScienceOn
24 Weng LP, Gimm 0, Kum JB, Smith WM, Zhou XP, Wynford- Thomas D, Leone G; Eng C, Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum. Mol. Genet. 2001, 10(3):251-8   DOI   ScienceOn
25 Zhao J, Huang WG, He J, Tan H, Liao QJ, SU Q, Diallyl disulfide suppresses growth of HL-60 cell through increasing histone acetylation and p21 WAF 1 expression in vivo and in vitro. Acta Pharmacol. Sin. 2006, 27(11): 1459-66   DOI   ScienceOn
26 Ali IV, Schriml LM, Dean M, Mutational spectra of PTENI MMACI gene: a tumor suppressor with lipid phosphatase activity. J. Natl. CancerInst. 1999, 91(22):1922-32   DOI
27 Chung TW, Lee YC, Ko JR, Kim CH, Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function ofp53, a transcriptional activator in liver cells. Cancer Res. 2003, 63(13):3453-8   PUBMED
28 Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS, TNFalpha upregulates PTEN via .NF-kappaB signaling pathways in human leukemic cells. Exp. Mol Med. 2007,39(1):121-7   DOI   PUBMED   ScienceOn
29 Park EK, K won KB, Park KI, Park BH, and Jhee EC, Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. Exp. Mol. Med. 2002, 34(3):250-7   DOI   PUBMED   ScienceOn
30 Eng C, Murday V, Seal S, Mohammed S, Hodgson SV, Chaudary MA, Fentiman IS, Ponder BA, Eeles RA, Cowden syndrome and Lhennitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J. Med. Genet. 1994, 31(6):458-61   DOI   ScienceOn
31 Leung KN, Mak NK, Fung MC, Hapel AJ, Synergistic effect ofIL-4 and TNF-alpha in the induction of monocytic differentiation of a mouse myeloid leukaemic cell line (WEHI -3B JCS). Immunology. 1994,81(1):65-72   PUBMED
32 Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H, Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumorselective death ligand TRAIL. Nat. Med. 2001, 7(6):680-6   DOI   ScienceOn
33 Liu KL, Chen HW, Wang RY, Lei YP, Sheen LY, Lii CK, DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages. J. Agric. Food Chem. 2006, 54(9):3472-8   DOI   ScienceOn
34 Hutt-Taylor SR, Hamish D, Richardson M, Ishizaka T, Denburg JA, Sodium butyrate and a T lymphocyte cell linederived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60. Blood. 1988, 71(1):209-15   PUBMED
35 Ferrero D, Tarella C, Gallo E, Ruscetti FW, Breitman TR, Terminal differentiation of the human promyelocytic leukemia cell line, HL-60, in the absence of cell proliferation. Cancer Res. 1982, 42(11):4421-6   PUBMED
36 Dirsch VM, Keiss HP, Vollmar AM, Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule Eselectin in human endothelial cells. Eur. J. Nutr. 2004, 43(1):55-9   DOI   ScienceOn
37 Davies MA, Koul D, Dhesi H, Bennan R, McDonnell TJ, McConkey D, Yung WK, Steck PA, Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMACIPTEN. Cancer Res. 1999, 59(11):2551-6   PUBMED
38 Grant S, Bhalla K, Weinstein B, Pestka S, Mileno MD, Fisher PB .. Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation. Biochem. Biophys. Res. Commun. 1985,130(1):379-88   DOI   ScienceOn
39 Knowles LM, Milner JA, Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. J. Nutr. 2003, 133(9):2901-6   PUBMED
40 Thejass P, Kuttan G, Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS). Life Sci. 2007, 80(6):515-21   DOI   ScienceOn
41 Lachyankar MB, Sultana N, Schonhoff CM, Mitra P, Poluha W, Lambert S, Quesenberry PJ, Litofsky NS, Recht LD, Nabi R, Miller SJ, Ohta S, Neel BG, Ross AH, A role for nuclear PTEN in neuronal diilerentiation. J. Neurosci. 2000, 20(4): 1404-13   PUBMED
42 Frwnan DA, Meyers RE, Cantley LC, Phosphoinositide kinases. Annu. Rev. Biochem. 1998, 67:481-507   DOI   ScienceOn
43 Lee JR, Kim KA, Kwon KB, Kim EK, Lee YR, Song MY, Koo JR, Ka SO, Park JW, Park BH, Diallyl disulfide accelerates adipogenesis in 3T3-Ll cells. Int. J. Mol. Med. 2007, 20(1):59-64   PUBMED
44 Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R, Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 1997, 16(1):64-7   DOI   ScienceOn
45 Weng LP, Smith WM, Dahia PL, Ziebold U, Gil E, Lees JA, Eng C, PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G 1 arrest followed by cell death .. Cancer Res. 1999, 59(22):5808-14   PUBMED
46 Sugatani T, Alvarez D, Hruska KA. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J. BioI. Chem. 2003, 278(7):5001-8   DOI   ScienceOn
47 Breitman TR, Selonick SE, Collins SJ, Induction of differentiation of the human promyelocytic leukemia cell line (HL- 60) by retinoic acid. Proc. Natl. Acad. Sci. U. S. A. 1980, 77(5):2936-40   DOI   ScienceOn
48 Fischkoff SA, Pollak A, Gleich GJ, Testa JR, Misawa S, Reber TJ, Eosinophilic differentiation ofthe human promyelocytic leukemia cell line, HL-60. J. Exp. Med.1984, 160(1): 179-96   DOI   ScienceOn
49 Huberman E and Callaham MF, Induction ofterminal differentiation in human promyelocytic leukemia cells by tumorpromoting agents. Proc Natl Acad Sci USA. 1979 Mar; 76(3): 1293-7   DOI   ScienceOn
50 Wen J, Zhang Y, Chen X, Shen L, Li GC, Xu M, Enhancement of diallyl disulfide-induced apoptosis by inhibitors of MAPKs in human HepG2 hepatoma cells. Biochem. Pharmacol. 2004, 68(2):323-31   DOI   ScienceOn
51 Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Woods WG, Ogden A, Weinstein H, Shepherd L, Willman C, Bloomfield CD, Rowe JM, Wiemik PH, Alltrans retinoic acid in acute promyelocytic leukemia: longterm outcome and prognostic factor analysis from the North American Intergroup protocol. Blood. 2002, 100(13):4298-302   DOI   ScienceOn
52 Zhang YW, Wen J, Xiao JB, Talbot SG, Li GC, Xu M, Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells. Arch. Pharm. Res. 2006, 29(12): 1125-31   DOI   ScienceOn
53 Zhang W, Wu N, Li Z, Wang L, Jin J, Zha XL, PPAR gamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404. Cancer BioI. Ther. 2006, 5(8): 1008-14   DOI   ScienceOn
54 Teresi RE, Shaiu CW, Chen CS, Chattetjee VK, Waite KA, Eng C, Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. Int. J. Cancer. 2006, 118(10):2390-8   DOI   ScienceOn
55 Cappellini A, Tabellini G, Zweyer M, Bortul R, Tazzari PL, Billi AM, Fala F, Cocco L, Martelli AM, The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip 1) and control of cyclin Dl expression. Leukemia. 2003, 17(11):2157-67   DOI   ScienceOn