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Thirteen-week Repeated Oral Dose Toxicity Study of WK-38 in Rats  

Chang, Bo-Yoon (College of Pharmacy, Wonkwang University)
Kim, Yoon-Chul (College of Pharmacy, Wonkwang University)
Kang, Dae-Gill (Korea Professional Graduate School of Oriental Medicine, Research Institute (MeRRI), Wonkwang University)
Lee, Ho-Sub (Korea Professional Graduate School of Oriental Medicine, Research Institute (MeRRI), Wonkwang University)
Kim, Sung-Yeon (College of Pharmacy, Wonkwang University)
Publication Information
Journal of Food Hygiene and Safety / v.23, no.2, 2008 , pp. 169-176 More about this Journal
Abstract
The subcronic toxicity of WK-38, a herbal preparation for the atherosclerosis, was examined in male and female Sprague-Dawley rats. WK-38 is composed of Rhei Rhizoma, Magonoliae Cortx, Moutan Cortex Radicis. Rats were treated with the test substance at a dose of 5 mg/kg, 50 mg/kg and 500 mg/kg intragastrically for 13 weeks. Control rats were treated with vehicle only. No death and abnormal clinical signs were observed throughout the administration period. Also there was no difference in net body weight gain, food and water consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of the WK-38. Hematological findings and biochemical examination revealed no evidence of specific toxicity related to WK-38. The results suggested that under the condition employed in this study no observation effect level (NOEL) of WK-38 would be 500 mg/kg/day.
Keywords
WK-38; repeated oral toxicity; Rats; Atherosclerosis;
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