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Antidiabetic Effect of Cordyceps militaris and Paecilomyces japonicus in Streptozotocin-induced Diabetic Rats  

정기화 (덕성여자대학교 약학대학)
정춘식 (덕성여자대학교 약학대학)
Publication Information
Journal of Food Hygiene and Safety / v.17, no.4, 2002 , pp. 210-215 More about this Journal
Abstract
To elucidate the effect of water and methanol extracts of Cordyceps militaris, Paecilomyces japonicus and their mycelin on diabetes and organs in STZ-induced diabetic rats, weight of organs (liver, kidney, spleen, thymus), plasma level of blood glucose, total protein, triglyceride, free fatty acid, hepatic total protein, triglyceride and glycogen were determined as compared with those of negative control group. The blood glucose level of CM-1 and CM-M group showed significantly reduced, and all groups except CM-2 increased in body weight. CM-1 decreased the liver weight, and PJ-2 decreased the kidney weight. In all groups except PJ-2, plasma total protein level was increased, and the triglyceride, and CM-3 and CM-H decreased the free fatty acid was decreased in CM-3, PJ-1 and PJ-2 treated groups. In hepatic tissue, total protein was significantly increased in CM-H and CM-M treated group, and in all groups except CM-2, the triglyceride were significantly decreased and glycogen was increased. In conclusion, CM-1 and CM-M that possess potential antidiabetic activity increased glycogen and lowered serum glucose level, thus they might improve metabolic disorder originated from diabetes by increasing serum protein and reducing excess triglyceride in serum and liver tissue.
Keywords
Cordyceps militaris; Paecilomyces japonicus; diabetes;
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