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http://dx.doi.org/10.23093/FSI.2019.52.3.261

Recent advances on next-generation probiotics linked to the gut microbiome  

Choi, Hak-Jong (R&D Division, World Institute of Kimchi)
Publication Information
Food Science and Industry / v.52, no.3, 2019 , pp. 261-271 More about this Journal
Abstract
Gut microbiome have recently provided evidence that the gut microbiota are capable of greatly influencing all aspects of physiology and immunology. Although a number of recent studies have shown that probiotics can modulate gut microbiota structure, the mechanism underlying this effect remains to be elucidated. In a disease state, the relative abundances of beneficial gut bacteria are generally reduced, which is restored by constant probiotic supplementation. Oral administration of probiotics improved the disease state by (1) inducing differentiation and function of regulatory T cells, (2) reducing inflammatory response, (3) modulating the gut environment, and (4) increasing the proportions of short-chain fatty acid- or beneficial metabolite-producing gut microbiota including the genera Bifidobacterium, Faecalibacterium, Akkermansia, etc. In this review, current knowledge on how probiotics can influence host's health by altering gut microbiota structure and on how probiotics and beneficial gut bacteria can be applied as next-generation probiotics will be discussed.
Keywords
gut microbiome; next-generation probiotics; functionality;
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