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http://dx.doi.org/10.9721/KJFST.2021.53.1.72

Evaluation of the effects of Hangover-releasing agent containing freeze-dried mature silkworm larval powder (SMSP) on alcohol metabolism and hangover improvement  

Woo, Miseon (Chong Kun Dang Healthcare Corporation)
Cha, Ji Hyeon (Department of Food Science and Bioechnology, Gachon University)
Kim, Yonghwan (Department of Family Medicine, Chungbuk National University Hospital)
Kang, Hee-Taik (Department of Family Medicine, Chungbuk National University Hospital)
Kim, Hyeondok (Chong Kun Dang Healthcare Corporation)
Cho, Kyong Won (Chong Kun Dang Healthcare Corporation)
Park, Sung Sun (Chong Kun Dang Healthcare Corporation)
Lee, Jong Hun (Department of Food Science and Bioechnology, Gachon University)
Publication Information
Korean Journal of Food Science and Technology / v.53, no.1, 2021 , pp. 72-77 More about this Journal
Abstract
Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.
Keywords
hangover improvement; silkworm (Bombyx mori) powder; alcohol metabolism; clinical trail research; cross-over model;
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