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http://dx.doi.org/10.9721/KJFST.2020.52.3.255

Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice  

Kim, Hyun Kyung (Department of Food and Nutrition, Hanyang University)
Jung, Jiyeon (Department of Food and Nutrition, Hanyang University)
Kang, Eun Young (Department of Food and Nutrition, Hanyang University)
Gang, Gyoungok (Department of Animal Science, Texas A&M University)
Kim, Wooki (Department of Food Science and Biotechnology, Kyung Hee University)
Go, Gwang-woong (Department of Food and Nutrition, Hanyang University)
Publication Information
Korean Journal of Food Science and Technology / v.52, no.3, 2020 , pp. 255-262 More about this Journal
Abstract
Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD+A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.
Keywords
anti-obesity therapeutic; Aronia melanocarpa; hormone-sensitive lipase; lipolysis; respiratory quotient;
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