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http://dx.doi.org/10.9721/KJFST.2020.52.3.249

Evaluation of anti-inflammatory effect by regulating NF-κB pathway of Argyreia capitata (Vahl) Choisy extract in LPS-induced RAW 264.7 macrophages  

Yeum, Ga Hee (School of Food Science and Biotechnology, Kyungpook National University)
So, Bo Ram (School of Food Science and Biotechnology, Kyungpook National University)
Bach, Tran The (Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology (VAST))
Eum, Sang Mi (International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology)
Jung, Sung Keun (School of Food Science and Biotechnology, Kyungpook National University)
Publication Information
Korean Journal of Food Science and Technology / v.52, no.3, 2020 , pp. 249-254 More about this Journal
Abstract
Argyreia capitata (Vahl) Choisy is a species of the genus Argyreia. Although many studies have analyzed the biological activity of A. nervosa, A. speciasa, and A. acuta, the anti-inflammatory effect of A. capitata extract (ACE) remains unclear. In this study, we evaluated the anti-inflammatory effect of ACE using lipopolysaccharide (LPS)-induced inflammatory markers in RAW 264.7 cells. We confirmed that the ACE inhibited the LPS-induced NO (nitric oxide) and iNOS (inducible nitric oxide synthase) expression in RAW 264.7 cells. ACE suppressed not only the LPS-induced phosphorylation of IKK, IκB, and p65 but also IL-1β expression. Collectively, these results suggest that ACE is a novel anti-inflammatory agent that suppresses iNOS expression, NO production, and the NF-κB signaling pathways.
Keywords
Argyreia capitata (Vahl) Choisy extract (ACE); nitric oxide (NO); NF-${\kappa}B$ (nuclear factor kappa-B); inflammatory cytokines; anti-inflammatory effect;
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