Browse > Article
http://dx.doi.org/10.9721/KJFST.2018.50.4.451

Anti-cancer effect of Sarijang on colorectal cancer cells in a xenograft nude mouse model  

Lee, Tae-Hee (Hoseo Toxicological Research Center, Hoseo University)
Song, Hyun-Kyung (Department of Bio Applied Toxicology, Graduate School of Hoseo University)
Kim, Dong-Yoon (Department of Bio Applied Toxicology, Graduate School of Hoseo University)
Lee, Isaac (Hoseo Toxicological Research Center, Hoseo University)
Seo, Hyeong-Ho (Insan Bamboo Salt Inc.)
Choi, Ji-Young (Insan Bamboo Salt Inc.)
Kim, Hong-Geun (Insan Bamboo Salt Inc.)
Choi, Eun-A (Insan Bamboo Salt Inc.)
Han, Beom-Seok (Hoseo Toxicological Research Center, Hoseo University)
Publication Information
Korean Journal of Food Science and Technology / v.50, no.4, 2018 , pp. 451-456 More about this Journal
Abstract
The current study was conducted to confirm the anti-cancer effect of Sarijang, which is a mixture of extracts from purple bamboo salt, Rhynchosia nulubilis, garlic, and Ulmi cortex. Nude mice were injected with a human-derived colorectal cancer cell (HCT116 cell line) and subsequently administered Sarijang for 4 weeks, following which the body weight, organ weight, and tumor size were measured. To evaluate the anti-cancer mechanism of Sarijang, the levels of p16 and extracellular signal-regulated kinase (ERK), cell cycle regulators in colorectal cancer, were measured. To evaluate the toxicity of Sarijang on liver and kidney, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine were analyzed. Sarijang not only reduced the tumor size by enhancing p16 and suppressing ERK, but also showed no side-effect in the liver and kidneys. Taken together, Sarijang has the potential to inhibit tumor growth without side effects, and may be used as a useful functional food.
Keywords
colorectal cancer; cell cycle; xenograft; Sarijang; ERK;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36: 131-149 (2003)   DOI
2 Zhao X, Deng X, Park KY, Qiu L, Pang L. Purple bamboo salt has anticancer activity in TCA8113 cells in vitro and preventive effects on buccal mucosa cancer in mice in vivo. Exp. Ther. Med. 5: 549-554 (2013)   DOI
3 Zhao X, Kim SY, Park KY. Bamboo salt has in vitro anticancer activity in HCT-116 cells and exerts anti-metastatic effects in vivo. J. Med. Food 16: 9-19 (2013)   DOI
4 Asada T, Ishihara S, Yamane T, Toba A, Yamada A, Oikawa K. Science of bamboo charcoal: study on carbonizing temperature of bamboo charcoal and removal capability of harmful gases. J. Health Sci. 48: 473-479 (2002)   DOI
5 Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm. Allergy Drug. Targets 9: 263-285 (2010)   DOI
6 de Leon MP. Familial and Hereditary Tumors. Springer, Switzerland. pp. 35-47 (1994)
7 Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW. CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc. Natl. Acad. Sci. 89: 2907-2911 (1992)   DOI
8 Florea AM, Busselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers 3: 1351-1371 (2011)   DOI
9 Gorinstein S, Jastrzebski Z, Namiesnik J, Leontowicz H, Leontowicz M, Trakhtenberg S. The atherosclerotic heart disease and protecting properties of garlic: contemporary data. Mol. Nutr. Food Res. 51: 1365-1381 (2007)   DOI
10 Hsieh CY, Santell RC, Haslam SZ, Helferich, WG, Estrogenic effects of genistein on the growth of estrogen receptor positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res. 58: 3833-3838 (1998)
11 Kim HY, Lee ES, Jeong JY, Choi JH, Choi YS, Han DJ. Effect of bamboo salt on the physicochemical properties of meat emulsion systems. Meat Sci. 86: 960-965 (2010)   DOI
12 Hu C, Zhang Y, Kitts DD. Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. Henonis leaf extract in vitro. J. Agr. Food. Chem. 48: 3170-3176 (2000)   DOI
13 Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A. HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc. Natl. Acad. Sci. 91: 10394-10398 (1994)   DOI
14 Ishimi Y. Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice. J. Nutr. 140: 1373-1376 (2010)   DOI
15 Kim CJ, Jung YS, Park JH, Kim HJ, Cho YK, Sohn CI, Bang KB. Prevalence, clinicopathologic characteristics, and predictors of interval colorectal cancers in Korean population. Intest. Res. 11: 178-183 (2013)   DOI
16 Kim EJ, Jang MK, Yoon EH, Jung CY, Nam DW, Lee SD. Efficacy of pharmacopuncture using root bark of Ulmus davidiana Planch in patients with knee osteoarthritis: a double-blind randomized controlled trial. J. Acupunct. Meridian St. 3: 16-23 (2010)   DOI
17 Lee MY, Seo CS, Ha H, Jung D, Lee H, Lee NH. Protective effects of Ulmus davidiana var. japonica against OVA-induced murine asthma model via upregulation of heme oxygenase-1. J. Ethnopharmacol. 130: 61-69 (2010)   DOI
18 Kim JG, Seo KW, Lee BH, Park MK, Park CW, Shin DW, Hong CM, Han SH, Kim YJ, Cho. 3 months repeated dose toxicity studies of the bamboo salt (Jukyum) in rats. Toxicol. Res. 18: 149-157 (2002)
19 Klaus SO, Ferrari DM, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. FEBS J. 254: 439-459 (1998)
20 Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257: 1689-1694 (1992)   DOI
21 Lee Y, Park H, Ryu HS, Chun M, Kang S, Kim HS. Effects of elm bark (Ulmus davidiana var. japonica) extracts on the modulation of immunocompetence in mice. J. Med. Food. 10: 118-125 (2007)   DOI
22 Li ZH, Kobayashi M. Plantation future of bamboo in China. J. For. Res.15: 233-242 (2004)   DOI
23 Pil PM, Lippard SJ. Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin. Science 256: 234-237 (1992)   DOI
24 Nielsen ILF, Williamson G. Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr. Cancer 57: 1-10 (2007)   DOI
25 Nierodzik ML, Karpatkin S. Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 10; 355-362 (2006)   DOI
26 Park HY, Choi YH, Choi EA. Anti-inflammatory effects of sarijang in lipopolysaccharide-activated BV2 microglial cells. Cancer Prev. Res. 16: 348-357 (2011)
27 Resch K, Ernst E. Garlic (Allium sativum) a potent medicinal plant. Fortschr. Med. 113: 311-315 (1995)
28 Rietjens IM, Sotoca AM, Vervoort J, Louisse J. Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Mol. Nutr. Food Res. 57: 100-113 (2013)   DOI
29 Shin HY, Na HJ, Moon PD, Shin T, Shin TY, Kim SH. Inhibition of mast cell-dependent immediate-type hypersensitivity reactions by purple bamboo salt. J. Ethnopharmacol. 91: 153-157 (2004)   DOI
30 Shin HY, Lee EH, Kim CY, Shin TY, Kim SD, Song YS. Antiinflammatory activity of Korean folk medicine purple bamboo salt. Immunopharmacol. Immunotoxicol. 25: 377-384 (2003)   DOI
31 Taylor CK, Levy RM, Elliott JC, Burnett BP. The effect of genistein aglycon on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutr. Rev. 67: 398-415 (2009)   DOI
32 Morgan DO. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell. Dev. 13: 261-291 (1997)   DOI