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http://dx.doi.org/10.9721/KJFST.2015.47.6.779

Effect of Dropwort (Oenanthe javanica) Extracts on Memory Improvement in Alzheimer's Disease Animal Model, Tg2576 mice  

Won, Beom Young (Research & Development Center, Braintropia Co., Ltd.)
Shin, Ki Young (Department of Microbiology, College of Natural Science, Dankook University)
Ha, Hyun Jee (Research & Development Center, Braintropia Co., Ltd.)
Chang, Keun-A (Department of Pharmacology, Gachon University of Medicine and Science)
Yun, Yeo Sang (Research & Development Center, Braintropia Co., Ltd.)
Kim, Ye Ri (Research & Development Center, Braintropia Co., Ltd.)
Park, Yong Jin (Research & Development Center, Braintropia Co., Ltd.)
Lee, Hyung Gun (Research & Development Center, Braintropia Co., Ltd.)
Publication Information
Korean Journal of Food Science and Technology / v.47, no.6, 2015 , pp. 779-784 More about this Journal
Abstract
This study was conducted to investigate the effect of herbs on memory improvement by focusing on their cholinergic functions in Tg2576 mice. Seven herbs were used to obtain extracts by using alcohol and water. In screening test for cholinergic activities of the extracts, acetylcholinesterase (AChE) activity was highly inhibited in Oenanthe javanica alcohol extract (OJAE, 18.76%) as compared with the others. The OJAE-treated Tg2576 (Tg-OJAE) groups showed the statistically significant increases of latency time in passive avoidance test. Also, it was found that the concentration of $A{\beta}1-42$ was significantly reduced in Tg-OJAE groups compared to non-treated Tg2576 groups. In the additional enzyme test, it was found that $IC_{50}$ of OJAE was $991.77{\mu}g/mL$ and OJAE acted as an uncompetitive inhibitor of AChE. Therefore, it seemed that OJAE can be used for the development of processed foods for memory improvement.
Keywords
Oenanthe javanica; memory; acetylcholinesterase; beta-amyloid; functional food;
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