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http://dx.doi.org/10.9721/KJFST.2015.47.3.394

Anti-atopic Effect of Hot Water and Supercritical Carbon Dioxide Fluid Extract of Persimmon (Diospyros kaki) Peels  

Cho, Byoung Ok (Ato Q&A Corporation)
Yin, Hong Hua (Ato Q&A Corporation)
Fang, Chong Zhou (Department of Health & Science, Jeonju University)
Shin, Jae Young (Department of Health & Science, Jeonju University)
Ha, Hye Ok (Department of Health & Science, Jeonju University)
Kim, Sang Jun (Jeonju Biomaterials Institute)
Jeong, Seung Il (Jeonju Biomaterials Institute)
Jang, Seon Il (Ato Q&A Corporation)
Publication Information
Korean Journal of Food Science and Technology / v.47, no.3, 2015 , pp. 394-400 More about this Journal
Abstract
This study aimed to investigate the anti-atopic effect of hot water (PPWE) and supercritical-carbon dioxide fluid extract of persimmon peels (SPPE) on atopic dermatitis (AD)-like skin lesions in hairless mice. Histological analyses demonstrated that SPPE treatment more strongly inhibited the dermal infiltration of inflammatory cells in AD-like skin lesions than that by PPWE. Compared to PPWE, SPPE significantly decreased the dermatitis clinical score and the epidermal thickness and potently suppressed serum IgE and interleukin (IL)-4 production in hairless mice with AD. Furthermore, compared to PPWE, SPPE potently inhibited the production of nitric oxide, prostaglandin $E_2$, and proinflammatory cytokines such as IL-6 and IL-$1{\beta}$ in lipopolysaccharide-stimulated RAW264.7 macrophages. These results suggested that SPPE exhibited anti-atopic dermatitis activity via the regulation of inflammatory responses.
Keywords
persimmon peels; supercritical fluid extract; atopic dermatitis; anti-inflammation;
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Times Cited By KSCI : 6  (Citation Analysis)
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