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http://dx.doi.org/10.9721/KJFST.2015.47.3.373

Amelioration of Trimethyltin-induced Cognitive Impairment in ICR Mice by Perilla Oil  

Kang, Jin Yong (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Bo Kyeong (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Seung, Tae Wan (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Chang Hyeon (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Park, Seon Kyeong (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Jin, Dong Eun (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Kang, Sung Won (S&T FOODS Co. Ltd.)
Choi, Sung-Gil (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Heo, Ho Jin (Division of Applied Life Science (BK21 plus).Institute of Agriculture and Life Science, Gyeongsang National University)
Publication Information
Korean Journal of Food Science and Technology / v.47, no.3, 2015 , pp. 373-379 More about this Journal
Abstract
This study aimed to investigate the anti-amnesic effect of perilla oil against trimethyltin (TMT)-induced learning and memory impairment in ICR mice. Perilla oil (2.5 mL/kg of body weight) and soybean oil (2.5 mL/kg of body weight) were administered orally to mice for 3 weeks, and at the end of the experimental period, cognitive behavior was examined by Y-maze and Morris water maze (MWM) tests. Behavioral tests showed that the mice treated with perilla oil had improved cognitive function compared to that in mice administered soybean oil. Analysis of brain tissue showed that perilla oil significantly lowered acetylcholinesterase activity and malondialdehyde (MDA) levels. Oxidized glutathione (GSH)-to-total GSH ratio also decreased from 10.4% to 5.3% in perilla oil-treated mice, but superoxide dismutase (SOD) activity increased from 11.7 to 14.2 U/mg protein. Therefore, these results suggest that the perilla oil could be a potential functional substance for improving cognitive function.
Keywords
acetylcholinesterase; cognition; perilla oil; soybean oil;
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