[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.9721/KJFST.2015.47.3.364

Co-treatment with Fermented Black Raspberry and Red Ginseng Extracts Improves Lipid Metabolism and Obesity in Rats Fed with a High-fat and High-cholesterol Diet

Lee, Min Jung (Gochang Black Raspberry Research Institute)
Choi, Hye Ran (Gochang Black Raspberry Research Institute)
Lee, Jung-Hyun (Gochang Black Raspberry Research Institute)
Lee, Su Jung (Gochang Black Raspberry Research Institute)
Kwon, Ji Wung (Gochang Black Raspberry Research Institute)
Choi, Kyung-Min (Institute of Jinan Red Ginseng)
Cha, Jeong-Dan (Institute of Jinan Red Ginseng)
Hwang, Seung-Mi (Institute of Jinan Red Ginseng)
Park, Jong Hyuk (Imsil Research Institute of Cheese Science)
Lee, Sang Cheon (Institute of Jinan Red Ginseng)
Park, Pill Jae (Gochang Agriculture Technology Center)
Lee, Tae-Bum (Gochang Black Raspberry Research Institute)

Publication Information

Korean Journal of Food Science and Technology / v.47, no.3, 2015 , pp. 364-372 More about this Journal

Abstract

This study investigated the effects of fermented black raspberry (BR) and red ginseng (RG) extract co-treatment on lipid metabolism and obesity in rats fed with a high fat/high cholesterol diet (HFHCD) for 12 weeks. Compared to the corresponding values in rats fed with a HFHCD, total cholesterol and low-density lipoprotein (LDL)-cholesterol and triglyceride levels decreased whereas high-density lipoprotein (HDL)-cholesterol levels increased in rats treated with fermented BR and RG extracts. These extracts significantly increased the expression of HMG-CoA reductase, LDL receptor, and sterol regulatory-element-binding protein-2 (SREBP-2) mRNA, but decreased the mRNA expression of SREBP-1. Additionally the serum levels of leptin and fatty acid synthase were decreased. Moreover, supplementation with fermented BR and RG effectively increased fecal cholesterol excretion. These results suggest that fermented BR and RG extracts might be effective at preventing hypercholesterolemia and obesity.

Keywords

black raspberry; red ginseng; lipid metabolism; obesity; fermented extract;

Citations & Related Records

Times Cited By KSCI : 8 (Citation Analysis)

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