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http://dx.doi.org/10.9721/KJFST.2014.46.3.288

Detection and Monitoring of Benzylpenicillin Residues in Livestock and Marine Products  

Lee, Hyo Jeong (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Kang, Young Won (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Lee, Soo Min (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
An, Kyung A (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Lee, Ryun Kyung (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Seo, Sang Cheol (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Lee, Ju Hee (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Im, Moo Hyeog (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Lee, Jeong Rim (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration)
Hong, Choong Man (Medical Products Safety Division, Seoul Regional Korea Food & Drug Administration)
Chang, Moon Ik (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation)
Cho, Yoon Jae (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation)
Publication Information
Korean Journal of Food Science and Technology / v.46, no.3, 2014 , pp. 288-294 More about this Journal
Abstract
Penicillin and its salts, including the benzatine, procaine, and sodium salts, have been widely used in human and veterinary medicine. Owing to their low toxicity, they currently form the most important group of antibiotics. However, overdose and abuse of these antibiotics may lead to potential risk in human health. Therefore, this study was conducted to validate the analysis method established by the Korea Food Code in 2012 and to monitor the levels of benzylpenicillin residues in products with reference to the maximum residue level (MRL). Of the 232 product samples tested, benzylpenicillin was detected in 11 livestock products and 2 marine products. Benzylpenicillin concentrations were found to be lower than the MRL in 12 products; however, the concentration of benzylpenicillin was found to be greater than the MRL in 1 pork product. The limit of quantification (LOQ) for benzylpenicillin was found to be 0.001-0.002 mg/kg, with an average recovery of 90.4-115.3%. Calibrations showed good linearity of 0.995 over a range of 0.002-0.05 mg/kg.
Keywords
benzylpenicillin; validation; monitoring; veterinary drug; MRLs;
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Times Cited By KSCI : 2  (Citation Analysis)
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