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http://dx.doi.org/10.9721/KJFST.2014.46.2.249

Single- and Repeated-dose Toxicities of Acanthopanax senticosus Fermentation Products in Rats  

Cho, Ju-Hyun (Hurum Central Research Institute Co., Ltd.)
Park, In-Jae (Hurum Central Research Institute Co., Ltd.)
Baik, Soon-Ok (Hurum Central Research Institute Co., Ltd.)
Choi, Soo-Young (College of Biology, Chungbuk National University)
Choi, Goo-Hee (Hurum Central Research Institute Co., Ltd.)
Publication Information
Korean Journal of Food Science and Technology / v.46, no.2, 2014 , pp. 249-255 More about this Journal
Abstract
In this study, the products of Acanthopanax senticosus fermentation were derived from the mycelia of 2 mushrooms, Ganoderma lucidum and Phellinus linteus, to determine their safety in Sprague-Dawley rats. Rats were orally administered the water extracts of A. senticosus fermentation products with G. lucidum (FM-5111) or P. linteus (FM-5131) at dose levels of 0.5, 1.0, or 2.0 g/kg for the single-dose toxicity test and 0.25, 0.5, or 1.0 g/kg for the repeated-dose toxicity test. There were no significant differences in body weight gain, feed intake, or water consumption between control and FM-5111- or FM-5131-treated rats. Hematological and blood biochemistry analysis revealed that none of the investigated parameters were affected by the A. senticosus fermentation products, and no remarkable lesions were observed upon histopathological analysis. We conclude that the A. senticosus fermentation products obtained from mushroom mycelia are safe for long-term administration and could be considered as multi-functional nutrients for the improvement of liver function and immunity.
Keywords
Acanthopanax senticosus fermentation; single-dose toxicity; repeated-dose toxicity; Ganoderma lucidum; Phellinus linteus;
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Times Cited By KSCI : 14  (Citation Analysis)
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