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http://dx.doi.org/10.9721/KJFST.2014.46.2.231

Anti-hyperlipidemic Activity of Albizzia julibrissin and Cassia tora L. Extract Mixtures in Rats Fed with High-fat Diets  

Nam, Jong-Hyun (Glami Co., Ltd.)
Sung, Kee-Seung (Korea Food Research Institute)
Lee, Jong Seok (Department of Food Science and Biotechnology, Kangwon National University)
Lee, Ok-Hwan (Department of Food Science and Biotechnology, Kangwon National University)
Han, Chan-Kyu (Korea Food Research Institute)
Publication Information
Korean Journal of Food Science and Technology / v.46, no.2, 2014 , pp. 231-236 More about this Journal
Abstract
The present study was undertaken to evaluate the anti-hyperlipidemic activity of Albizzia julibrissin and Cassia tora L. extract mixtures in high fat diet-induced hyperlipidemic rats. In high-fat diet fed hyperlipidemic rats, oral treatment with Albizzia julibrissin and Cassia tora L. extracts resulted in decreased levels of total serum cholesterol and triglycerides, epididymal fat pad (EFP) weights, and activities of hepatic glucose-6-phosphate dehydrogenase (G6PDH) and malic enzyme, while the levels of feces production and high-density lipoprotein (HDL)-cholesterol were increased, compared with untreated control. Therefore, these results suggest that Albizzia julibrissin and Cassia tora L. extract mixtures can ameliorate hyperlipidemia.
Keywords
Albizzia julibrissin; Cassia tora L.; high-fat diet; lipid profiles;
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Times Cited By KSCI : 12  (Citation Analysis)
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1 Chung SI, Kim SE, Kang MY. Characteristics of surimi gel (king oyster mushroom and cuttlefish meat paste) on lipid metabolism and antioxidant status in high-cholesterol-fed rats. Korean J. Food Sci. Technol. 41: 191-195 (2009)   과학기술학회마을
2 Kim AJ, Kim SY, Choi MK, Kim MH, Han MR, Chung KS. Effects of mulberry leaves powder on lipid metabolism in high cholesterol-fed rats. Korean J. Food Sci. Technol. 37: 636-641 (2005)   과학기술학회마을
3 Edijala JK, Asagba SO, Eriyamremu GE, Uzezi A. Comparative effects of garden egg fruit oat and apple on serum lipid profile in rats fed on a high cholesterol diet. Pak. J. Nutr. 4: 245-249 (2005)   DOI
4 Yamamoto A, Sudo H, Endo A. Therapeutic effects of ML-236B in primary hypercholesterolemia. Atherosclerosis 35: 259-266 (1980)   DOI
5 Kim IS, Chae SC, Kim DW. Effects of onion and naringin extract mixed products on antihyperlipidemic levels of bio FIB hamster. Korean J. Microscopy 39: 191-197 (2009)   과학기술학회마을
6 Endo A, Tsujita Y, Kuroda M, Tanzawa K. Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals. Biochim. Biophys. Acta. 575: 266-276 (1979)   DOI   ScienceOn
7 Tsujita Y, Kuroda M, Tanzawa K, Kitano N, Endo A. Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3- hydroxy-3-methylglutaryl coenzyme A reductase. Atherosclerosis 32: 307-313 (1979)   DOI
8 Keys A. Alpha lipoprotein (HDL) cholesterol in the serum and the risk of coronary heart disease and death. Lancet. 2: 603-606 (1980)
9 Brown SL. Lowered serum cholesterol and low mood. Brit. J. Med. 313: 637-638 (1996)   DOI   ScienceOn
10 Irudayaraj SS, Sunil C, Duraipandiyan V, Ignacimuthu S. In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. Leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. Food Chem. Toxicol. 60: 135-140 (2013)   DOI   ScienceOn
11 Kaneda M, Morishita E, Shibata S. Chemical studies on the oriental plant drugs. XXI. The constituents of Cassia tora L. 2. A glycoside of rubrofusarin. Chem. Pharm. Bull. 17: 458-461 (1969)   DOI   ScienceOn
12 Dhanasekaran M, Ignacimuthu S, Agastian P. Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in Wistar rats. Phytomedicine 16: 891-895 (2009)   DOI   ScienceOn
13 Patil UK, Saraf S, Dixit VK. Hypolipidemic activity of seeds of Cassia tora Linn. J. Ethnopharmacol. 90: 249-252 (2004)   DOI   ScienceOn
14 Kinjo A, Araki K, Fukui K, Higuchi H, Ikeda T, Nohara T, Ida Y, Takemoto N, Miyakoshi M, Shoji J. Six new triterpenoidal glycosides including two new sapogenols from Albizziae Cortex. V. Chem. Pharm. Bull. (Tokyo) 40: 3269-3273 (1992)   DOI   ScienceOn
15 Kim YH. Isolation of acylated sterylglycosides from the legumes of Albizzia julibrissin. Kor. J. Pharmacogn. 30: 290-294 (1999)   과학기술학회마을
16 Kang TH, Jeong SJ, Kim NY, Higuchi R, Kim YC. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J. Ethnopharmacol. 71: 321-323 (2000)   DOI   ScienceOn
17 Chen SP, Zhang RY, Ma LB, Tu GZ. Structure determination of three saponins from the stem bark of Albizzia julibrissin Durazz. Acta. Pharm. Sinic. 32: 110-115 (1997)
18 Woo WS, Kang SS. Isolation of a new monoterpene conjugated triterpenoid from the stem bark of Albizzia julibrissin. J. Nat. Prod. 47: 547-549 (1984)   DOI
19 Yun JS, Chung BH, Kim NY, Seong NS, Lee HY, Lee JH, Kim JD. Screening of 94 plant species showing ACE inhibitory activity. Korean J. Medicinal Crop Sci. 11: 246-251 (2003)   과학기술학회마을
20 Jang KG, Oh HC, Ko EK, Kang KH, Park SE, Oh MH, Kim YC. Free radical scavengers from the leaves of Albizzia julibrissin. Kor. J. Pharmacogn. 33: 18-20 (2002)   과학기술학회마을
21 Choi BD, Ryeom K. Cytotoxicity of the components of Albizzia julibrissin. J. Appl. Pharmacol. 7: 371-376 (1999)   과학기술학회마을
22 Won HJ, Han CH, Kim YH, Kwon HJ, Kim BW, Choi JS, Kim KH. Induction of apoptosis in human acute leukemia Jurkat T cells by Albizzia julibrissin extract is mediated via mitochondria-dependent caspase-3 activation. J. Ethnopharmacol. 106: 383-389 (2006)   DOI   ScienceOn
23 Bergmeyer HU. 1974. In methods of enzymatic analysis. 2nd English ed., Academic press. Inc., New York and London, Vol. 1, p. 458-450
24 Ochoa S. 1969. In methods in Enzymology (Lewenstein JM, ed.) Academic press. Inc., New York, Vol. 13, p. 230-231.
25 Park YJ, Jung WC, Jeong DY, Lee YU, Lee I, Lee KS, Jeon BH, Sung KK, Moon BS. Effects of the water extract from Albizzia julibrissin on apoptosis and cell cycle progression in the human leukemic Jurkat cells. Korean J. Orient. Physiol. Pathol. 17: 1383-1392 (2003)   과학기술학회마을
26 Rudel L, Morris MD. Determination of cholesterol using O-phthalaldehyde. J. Lipid Res. 14: 364-366 (1973)
27 Noma A, Nakayama KN, Kita M, Okabe H. Stimultaneous determination of serum cholesterol in high and low density lipoprotein with use of heparin, $Ca2^+$ and an anion exchange resin. Clin. Chem. 24: 1504-1508 (1978)
28 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275 (1951)
29 Han CK, Kim SS, Choi SY, Park JH, Lee BH. Effects of rice added with mulberry leaves and fruit on blood glucose, body fat and serum lipid levels in rats. J. Korean Soc. Food Sci. Nutr. 38:1336-1341 (2009)   과학기술학회마을   DOI
30 Lee YS, Hong CK, Seo SJ, Kim NW. Analysis on the useful nutrition components of the Albizzia julibrissin stems and leaves. J. Korean Soc. Food Sci. Nutr. 39: 1143-1148 (2010)   과학기술학회마을   DOI   ScienceOn
31 Hong KH, Choi WH, Ahn JY, Jung CH, Ha TY. Physicochemical properties of ethanol extracts and dietary fiber from Cassia tora L. seed. Korean J. Food Nutr. 25: 612-619 (2012)   과학기술학회마을   DOI   ScienceOn
32 Avram AS, Avram MM, James WD. Subcutaneous fat in normal and diseased states: 2. Anatomy and physiology of white and brown adipose tissue. J. Am. Acad. Dermatol. 53: 671-683 (2005)   DOI   ScienceOn
33 Park EJ, Choi SW, Cho SH. Effects of the purified extracts from Lycii Cortex Radicis and ginger on lipid status and serum cytokine levels in rats fed high fat diet. Korean J. Nutr. 45: 411-419 (2012)   DOI
34 Connor WE, Stone DB, Hodges RE. The interrelated effects of dietary cholesterol and fat upon human serum lipid levels. J. Clin. Invest. 43: 1691-1696 (1964)   DOI   ScienceOn
35 Han ZZ, Xu HD, Kim KH, Ahn TH, Bae JS, Lee JY, Gil KH, Lee JY, Woo SJ, Yoo HJ, Lee HK, Kim KH, Park CK, Zhang HS, Song SW. Reference data of the main physiological parameters in control Sprague-Dawley rats from pre-clinical toxicity studies. Lab. Anim. Res. 26: 153-164 (2010)   과학기술학회마을   DOI
36 Ha TY, Cho IJ, Seong KS, Lee SH. Effect of Cassia tora ethanol extract on the lipid levels of serum and liver in rats fed high cholesterol diet. J. Korean Soc. Food Sci. Nutr. 30: 1171-1176 (2001)   과학기술학회마을
37 Chung MH, Lee BJ, Kim GW. Studies on antihyperlipemic and antioxidant activity of Allium cepa L. Kor. J. Pharmacogn. 28: 198-208 (1997)
38 Yugarani T, Tan BK, Teh M, Das NP. Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Lipids 27: 181-186 (1992)   DOI   ScienceOn
39 Lee HJ, Choi MS. Measurement of inhibitory activities on hydroxyl-3-methylglutaryl CoA reductase and acyl-CoA: Cholesterol acyltransferase by various plant extracts in vitro. J. Korean Soc. Food Sci. Nutr. 28: 958-962 (1999)   과학기술학회마을
40 Kim KS, Park JS. Effect of Artemisia kwayomogi water extract on hepatic injury by carbon tetrachloride in rats II, Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content. Kor. J. Vet. Res. 32: 357-364 (1992)
41 Lee WC, Kim AJ, Kim SY. The study on the functional materials and effects of mulberry leaf. Food Sci. Ind. 36(3):2-14 (2003)
42 Ha TY, Cho IJ, Lee HY. Effect of Cassia tora ethanol extracts on carbon tetrachloride-induced liver injury in rats. Korean J. Food Sci. Technol. 33: 789-794 (2001)   과학기술학회마을
43 Boll M, Weber LW, Stampfl A. Nutritional regulation of the activities of lipogenic enzymes of rat liver and brown adipose tissue. Z. Naturforsch. C. 51: 859-869 (1996)
44 Nishikawa S, Doi K, Nakayama H, Uetsuka K. The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet. Toxicol. Pathol. 36: 850-857 (2008)   DOI
45 Um MY, Ahn JY, Ha TY. Hypolipidaemic effects of cyanidin 3-glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities. J. Sci. Food Agr. 93: 3126-3128 (2013)   DOI   ScienceOn
46 Ueda M, Okazaki M, Ueda K, Yamamura S. A leaf-closing substance of Albizzia julibrissin Durazz. Tetrahedron 56: 8101-8105 (2000)   DOI   ScienceOn