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http://dx.doi.org/10.9721/KJFST.2014.46.2.219

Protective Effects of Fucoidan against Acute Alcohol-induced Liver Injury in Rats  

Kim, Mi-Ja (College of Biotechnology and Bioengineering Bioengineering, Sungkyunkwan University)
Jeon, Joseph (Haewon Biotech, Inc.)
Lee, Sung Pyo (Misuba RTech Co., Ltd.)
Lee, Jin-Sil (Department of Foodservice Management and Nutrition, Sangmyung University)
Publication Information
Korean Journal of Food Science and Technology / v.46, no.2, 2014 , pp. 219-223 More about this Journal
Abstract
The purpose of this study was to investigate the protective effects of fucoidan on acute alcohol-induced liver injury in rats. Experimental animals were randomly divided into four groups: (1) a control group, (2) a group fed 25% ethanol, (3) a group fed 25% ethanol and 250 mg/kg BW of fucoidan (25% ethanol+FUCO250), and (4) a group fed 25% ethanol and 500 mg/kg BW of fucoidan (25% ethanol+FUCO500). Each group was fed orally two times per day for 15 days. Liver weights in the 25% ethanol group were increased compared to the control group, while liver weights in the 25% ethanol+FUCO500 group were significantly decreased compared to the 25% ethanol group (p<0.05). Plasma concentrations of triglyceride, cholesterol, and LDL-cholesterol were elevated in the 25% ethanol group; however, these levels in the 25% ethanol+FUCO250 group were significantly decreased compared to the 25% ethanol group (p<0.05). The glutamic-pyruvic transaminase activity of the 25% ethanol+FUCO500 group also was significantly lower than the 25% ethanol group (p<0.05). These results indicate that fucoidan might protect against acute alcohol-induced liver injury.
Keywords
acute alcohol injury; fucoidan; glutamic-pyruvic transaminase; liver injury;
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Times Cited By KSCI : 7  (Citation Analysis)
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