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http://dx.doi.org/10.9721/KJFST.2011.43.2.189

Anti-obesity Effect of Sargassum confusum Ethanol Extract in Obese Rats  

Jang, Yu-Jung (Neo Food Resources Research Group, Korea Food Research Institute)
Kwon, Sang-Oh (R&D Center, S&D Co., Ltd.)
Yeo, Kyung-Mok (R&D Center, S&D Co., Ltd.)
Hong, Mi-Jung (R&D Center, S&D Co., Ltd.)
Kim, Bok-Nam (Department of Tourism and Food Service Cuisine, Hallym College)
Han, Dae-Seok (Neo Food Resources Research Group, Korea Food Research Institute)
Publication Information
Korean Journal of Food Science and Technology / v.43, no.2, 2011 , pp. 189-194 More about this Journal
Abstract
Effect of Sargassum confusum extract on the reduction of body weight gain and lipid contents in obese rats were evaluated to find natural materials with anti-obesity benefits. After inducing obesity by feeding 42.5% high-fat diet for 5 weeks, each 10 Sprague-Dawley rats were randomly assigned to high-fat diet control (HFD) group and high-fat diet group containing 3% Sargassum confusum extract (HFDSC). Weight gain of HFD group ($2.96{\pm}0.31g/day$) was significantly (p<0.05) higher as compared to that of normal diet (ND) group ($2.19{\pm}0.17g/day$). Weights of adipose tissues of HFD group were higher than those of ND group. Body weight gain of HFDSC group, however, was $2.36{\pm}0.24g/day$, which was significantly (p<0.05) lower by 21% than that of HFD group. In addition, weights of epididymal and perirenal adipose tissues were lower by 15% and 16%, respectively, as compared to those of HFD group. Biochemical analyses showed that concentration of triglyceride, total cholesterol, and fatty acids were significantly (p<0.05) lower in HFDSC group. These results suggest that Sargassum confusum extract has a high potential as an anti-obesity material by reducing weight gain and obesity-related factors in serum.
Keywords
Sargassum confusum; anti-obesity; high-fat diet; weight gain; adipose tissue;
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