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Effects of Perilla frutescens Extract on Anti-allergic Reactions in a Mouse Model  

Ko, Jung-A (School of Life Sciences and Biotechnology, Korea University)
Lim, Hun-Sun (Department of Bio R&D, Korea Medi Co. Ltd.)
Kim, Gun-Hee (Department of Food and Nutrition, DukSung Women's University)
Park, Ji-Yong (Department of Biotechnology, Yonsei University)
Han, Chan-Kyu (Korea Food Research Institute)
Park, Hyun-Jin (School of Life Sciences and Biotechnology, Korea University)
Publication Information
Korean Journal of Food Science and Technology / v.42, no.4, 2010 , pp. 488-493 More about this Journal
Abstract
We investigated the effect of Perilla frutescens (PF) ethanol extract powder (PF-E30) on the local allergic reaction activated by anti-DNP IgE and the mast cell-mediated immediate-type allergic reactions induced by compound 48/80 in a mouse model. One gram of PF powder extracted with 30% ethanol at $80^{\circ}C$ contained 12.3 mg of rosmarinic acid. Oral administration of PF-E30 (0.1 to 0.5 mg/kg body weight) significantly reduced plasma histamine levels and inhibited histamine release from peritoneal mast cells in mice activated by compound 48/80 or anti-DNP IgE. Moreover PF-E30 dose-dependently inhibited the production of antigen-induced IgE. These results indicate that the PF ethanol extract inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.
Keywords
Perilla frutescens; rosmarinic acid; anti-allergic reaction; histamine; antigen-induced IgE;
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