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Induction of Apoptosis by Immature Prunus salicina Lindl. cv. Soldam  

Yu, Mi-Hee (Department of Food Science and Technology, Keimyung University)
Im, Hyo-Gwon (Department of Food Science and Technology, Keimyung University)
HwangBo, Mi-Hyang (Department of Food Science and Technology, Keimyung University)
Lee, Ji-Won (Department of Food Science and Technology, Keimyung University)
Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.2, 2005 , pp. 221-227 More about this Journal
Abstract
Apoptosis of Prunus salicina Lindl. cv. Soldam, which possesses hematopoiesis, osteoporosis prevention, and antimutagenic effects, at different growth stages was evaluated. Cytotoxic effect of acetone extracts of immature fruits against various tumor cell lines was higher than that of mature fruits, particularly in hormone-independent human breast cancer, MDA-MB-231 cell line. Immature fruit extract increased expression level of pro-apoptotic protein Bax and reduced that of anti-apoptotic protein Bcl-2, and stimulated caspase-3 activity in MDA-MB-231 cells. Results suggest immature fruit of P. salicina Lindl. cv. soldam to be natural source for development of functional food and medical agents to prevent human breast cancer.
Keywords
Prunus salicina Lindl. cv. Soldam; apoptosis; human breast cancer;
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