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http://dx.doi.org/10.7856/kjcls.2015.26.1.103

Effects of Korean and Chinese Crataegi Fructrus on the Antioxidant Activity and Antiproliferation of Cancer Cells  

Park, Yonghyun (Dept. of Food and Nutrition, Chosun University)
Lee, Hyun-Joo (Dept. of Nutrition and Culinary Science, Hankyoung National University)
Lee, Jae-Joon (Dept. of Food and Nutrition, Chosun University)
Publication Information
The Korean Journal of Community Living Science / v.26, no.1, 2015 , pp. 103-113 More about this Journal
Abstract
This study examines the effects of Korean Crataegi fructrus(KCF) and Chinese Crataegi fructrus(CCF) on the antioxidative activity and antiproliferation of human cancer cells(HCT-116 human colon, Hep G2 human liver, and A549 human lung cancer cells). The total polyphenol and flavonoid contents, and antioxidative index of the Crataegi fructrus ethanol extracts were significantly higher in KCF than in CCF. The DPPH radical-scavenging activity of the KCF ethanol extract was 82.26%(1000 ppm), and that of the CCF ethanol extract was 77.64%. Antiproliferation effects of 80% ethanol extracts of KCF and CCF on human cancer cells(HCT-116, Hep G2 and A549) increased in a dose-dependent manner. Inhibitory effects of KFC on HCT-116 and A549 cells were greater than those of CCF. The results suggest that ethanol extracts of Crataegi fructrus have antioxidative and hyperplasia inhibition effects on human cancer cells.
Keywords
Crataegi fructrus; antioxidative effect; cytotoxic effect; human cancer cell lines;
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Times Cited By KSCI : 17  (Citation Analysis)
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