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Anti-inflammatory Effect of Aloe Vera and Aloe Arborescens in Phosphatidic Acid-stimulated Raw Cells  

Cho, Young-Je (Department of Food Engineering, Sangju National University)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Hanny University)
Kim, Myung-Uk (R&D Center, Kimjeongmoonaloe Co. LTD.)
Shim, Chang-Sub (R&D Center, Kimjeongmoonaloe Co. LTD.)
Publication Information
Applied Biological Chemistry / v.49, no.1, 2006 , pp. 65-69 More about this Journal
Abstract
With extracted Aloe vera and Aloe arborescens, anti-inflammatory effect was examined in phosphatidic acid-stimulated Raw 264.7 cells. Phosphatidic acid $(50\;{\mu}g/ml)$ treatment increased inflammation related 264.7 cells. The extracts of $80\;{\mu}g/ml$ concentration from Aloe arborescens reduced the expression of iNOS. Aloe vera and Aloe arborescens also reduced the expression of COX-2, it seems that anti-inflammatory effects of Aloe extracts is partly due to the inhibition of COX-2 expression by inhibiting in Raw 264.7 cells.
Keywords
Aloe vera; Aloe arborescens; anti-inflammatory effect;
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1 Chung, J. H., Rubin, R. J. and Cha, Y. N. (1993) Effect of vitamin $K_{1}$ and menadione on rthanol metabolism and toxicity. Drug Chem. Toxicol. 16, 383-394   DOI
2 Gross, S. S. and Wolin, M. S. (1995) Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol. 57, 737-769   DOI   ScienceOn
3 Stuehr, D. J. (1999) Mammalian nitric oxide synthase. Biochem. Biophys. Acta 411, 217-230
4 Byun, S. H., Yang, C. H. and Kim, S. C. (2005) Inhibitory effect of Scrophulariae Radix extract on TNF-${\alpha}, IL-$1{\ beta}, IL-6 and nitric oxide production in lipopolysaccharide-activated Raw 164.7 cells. Kor. J. Herbol. 20, 7-16
5 Fujita, K., Teraira, R. and Nagatsu, T. (1976) Bradykininase acitivity of aloe extracts. Biochem. Pharmacol. 25, 205-209   DOI   ScienceOn
6 Kroncke, K. D., Fehsel, K. and Kolb-Bachofen, V. (1998) Inducible nitric oxide synthase in human diseases. Clin. Exp. Immunol. 113, 147-156   DOI
7 Kim, S. C., Jung, Y. S., Lee, J. R., Kim, Y. W., Byun, B. H., Kwon, T. K., Suh, S. I., Byun, S. H. and Kwon, Y. K. (2004) Inhibition effect of Phellinus lgniarius water extract on TNF-${\alpha}$, IL-$1{\beta}$, IL-6 and nitric oxide production in lipopolysaccharide-activated Raw 164.7 cells. Korean J. Ori. Phy. Pathol. 18, 880-886
8 Yagi, A., Harada, N., Yamada, H., Iwadare, S. and Nishioka, I. (1982) Antibradykinin active material in Aloe saponaria. J. Pharm. Sci. 71, 1172-1175   DOI
9 So, M. S., Lee, J. S. and Yi, S. Y. (2004) Inhibition of nitric oxide and cytokines in Macrophages by Codonopsis lanceolata. Kor. J. Food Sci. Technol. 36, 986-990
10 Suh, Y. J., Chun, K. S., Cha, H. H., Han, S. S., Keum, Y. S., Park, K. K. and Lee, S. S. (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. 480, 243-268
11 Minter, M., Towbin, J., Harter, J. and McCabe, E. R. (1989) Enzyme product blot for nondestructive assay of protein catalytic function in polyacrylamide gels. Anal Biochem. 178, 22-26   DOI   ScienceOn
12 Suh, Y. J. (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol. 40, 1091-1097   DOI   ScienceOn
13 Chung, J. H., Cha, Y. N. and Rubin, R. J. (1994) Role of quinone reductase in ethanol metabolism and toxicity. Toxicol. Appl. Pharmacol. 124, 123-130   DOI   ScienceOn
14 John, S. H. (1990) A drug for all seasins medical and pharmacological history of aloe. Bull. N.Y. Acad. Med. 66, 647-659
15 Oshima, H. and Bartsch, H. (1994) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. 305, 253-264   DOI
16 Grindlay, D. and Reynolds, T. (1986) The Aloe Vera phenomenon: A review of the properties and modem uses of the leaf parencyma gel. J. Ehnopharmacol. 16, 117-151   DOI   ScienceOn
17 Jung, M. H. (1998) Usefulness of aloe food. Symposium on health foods, pp. 15-25