Browse > Article

Cytotoxic Effects of Some Transition Metals, Nickel(II), Copper(II) and Zinc(II), with 3.6-bis(2'-pyridyl)pyridazines Complexes  

Kwon, Byung-Mok (Korea Research Institute of Chemical Technology, Protein Regulator R.U.)
Lee, Chong-Ock (Screening and Toxicology Research Center, Korea research Institute of Chemical Technology)
Choi, Sang-Un (Screening and Toxicology Research Center, Korea research Institute of Chemical Technology)
Sung, Nack-Do (Research Center for Transgenic Cloned Pigs, Chungnam National University)
Publication Information
Applied Biological Chemistry / v.49, no.1, 2006 , pp. 21-24 More about this Journal
Abstract
A series of cytotoxic activities $(ED_{50})$ in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, $3{\sim}6$ were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis- [3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin.
Keywords
3,6-bis(6'-methyl-2'-pyridyl)pyridazine; transition metal complexes; cytotoxic activity; human cancer cell lines;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Lichtenstein, A. K. and Pendde, D. (1986) Enhancement of natural killer cytotoxicity by cis-diaminedichloroplatinum(II) in vivo and in vitro. Cancer Res. 46, 639-644
2 Shrivastav, A., Singh, N. K. and Singh, S. M. (2002) Synthesis, characterization and antitumor studies of Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of N-salicyloyl-N'-O-hydroxythiobenzhydrazide. Bioorg. Med. Chem. 10, 887-895   DOI   ScienceOn
3 Sung, N. D., Yun, K. S., Kim, J. G. and Suh, I. H. (2000) $\mu$-Aqua-pentaaqua[$\mu$-3,6-bis(6-methyl-2- pyridyl)pyridazine] chlorodinickel(II) trichloride trihydrate. Acta. Cryst. C56, e370-e371
4 Choi, K. Y., Sung, N. D., Yun, K. S., Park, Y. S., Kim, J. G. and Suh, I. H. (2001) Bis[3,6-bis(6'-methyl-2'-pyridyl) pyridazine-$k^{2}N^{2}N^{3}$]chlorocopper(II) perchlorate. Acta. Cryst. C57, 47-48
5 Kim, M. J., Lee, J. H., Lee H. J. and Sung, N. D. (1999) The crystal structure of [3,6-bis(6'-methyl-2'-pyridyl)pyridazine] $ZnCI_{2},C_{16}H_{16}N_{4}.ZnCI_{2}$. Kor. J. Crystall. 10, 119-124
6 Sung, N. D., Yun, K. S., Kim, T. Y., Choi, K. Y., Suh, M., Kim, G. J., Suh, I. H. and Chin, J. (2001) Synthesis and characterization of a novel tetranuclear nickel(II) complex: [$Ni_{4}({\mu}-OH)_{2}({\mu}-dppn)_{4}({\mu}-H_{2}O)_{2}](Cl)(ClO_{4})_{5}\;9H_{2}O$, (dppn=3,6-bis(2'-pyridyl)pyridazine). Inorg. Chem. Comm. 4, 377-380   DOI   ScienceOn
7 Choi, S. U., Choi, E. J., Kim, K. H., Kim, N. Y., Kwon, B. M., Kim, S. U., Bok, S. H., Lee, S. Y. and Lee, C. O. (1996) Cytotoxicity of trichlorothecenes to human solid tumor cells in vitro. Arch. Pharm. Res. 19, 6-11   DOI
8 TOPKAT (The open practical knowledge acquisition toolkit). Accelrys Inc., Web: http:/www.accelrys.com
9 Sung, N. D. and Yoon, K. S. (2005) The roles of metal ions and water molecules in the hydrolysis of bis(p-nitrophenyl)-phosphate as a DNA model catalyzed by dinuclear Ni(II) complex. J. Kor. Soc. Appl. Biol. Chem. 48, 115-119   과학기술학회마을
10 Sung, N. D., Kim, D. W., Kwon, B. M., Kim, T. Y. and Suh, I. H. (2000) Biological activities of some organometallic compounds as artificial nuclease. Kor. J. Pestic. Sci. 4, 32-37
11 Rosenberg, B. (1980) In Nucleic-Metal Ion Interactions: Platium Complexes for the Treatment of Cancer. Spiro, T. G. (ed.). Ch. 1., John Wiley & Sons, New York
12 Marzano, C., Trevisan, A., Giovagnini, L. and Fregona, D. (2002) Synthesis of new platinum(II) complex: anticancer activity and nephrotoxicity in Vitro. Toxicology in Vitro. 16, 413-419   DOI   ScienceOn
13 Wall. M., Hynes, R. C. and Chin, J. (1993) Double Lewis acid activition in phosphate diester clavage, Angew, Chem. Int. Ed. Engl. 32, 1633-1635   DOI   ScienceOn
14 Dugas, H. (1989) In Bioorganic Chemistry: A chemical approach to enzyme action (3rd Ed.). Ch. 3, Springer-Verlag, New York. pp. 128-132
15 Sung, N. D. (1998) The transition state analog for metal catalized hydrolysis an ester, Agric. Chem. Biotech. 4, 410-411
16 Sung, N. D., Seo, J. S., Rosemary, C. H. and Chin, J. (1996) Structure and reactivity of a dinuclear cobalt(III) complex with a bridging phosphate monoester. Inorg. Chem. 35, 7472-7473   DOI   ScienceOn
17 Liu, C., Wang, M., Zhang, T. and Sun, H. (2004) DNA hydrolysis promoted by di- and multi-nuclear metal complexes. Coordination Chem. Rev. 248, 147-168   DOI   ScienceOn
18 Fujita, T. (1983) In Progress in Physical Organic Chemistry Substitution effects in the partition coefficient of disubstituted benzenes: Bidirectional Hammett-type relationships. Vol. 14, Taft, R. W.(ed.). John Wiley & Sons., Toronto. pp. 75-113
19 Paxton, R. J., Beatty, B. G., Hawthorne, M. F., Varadarajan, A., Williams, L. E., Curtis, F. L., Knobler, C. B., Beatty, J. D. and Shively, J. E. (1991) A transition metal complex (Venus flytrap cluster) for radioimmunosdetection and radioimmuno-therapy. Proc. Natl. Acad. Sci. USA 88, 3387-3391
20 Kleinerman, E. S., Zwelling, L. A. and Muchmore, A. V. (1980) Enhancement of naturally ocuring human spontaneous monocyte-mediated cytotoxicity by cis-diaminedichloroplatinum (II). Cancer Res. 40, 3099-3102
21 Sherman, S. E. and Lipoard, S. J. (1987) Structural aspects of plantinum anticancer drug interactions with DNA. Chem. Rev. 87, 1153-1181   DOI
22 Rosenberg, B. (1978) Platinum complexes for the treatment of cancer. Interdisc. Sci. Rev. 3, 134-147   DOI
23 Sung, N. D., Seo, J. S., Rosemary, C. H., Williams, D. and Chin, J. (1998) Structure and reactivity of a dinuclear cobalt(III) complex with peroxide and phosphate diester analogues bridging the metal ions. J. Am. Chem. Soc. 120, 9943-9944   DOI   ScienceOn
24 Williams, N. H. (2004) Models for biological phosphoryl transfer. Biochem. Biophys. Acta 279-287
25 Cowan, J. A. (2001) Chemical nucleases. Curr. Opin. Chem. Biol. 5, 634-642   DOI   ScienceOn