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Isolation of Anthraquinone Derivatives from the Root of Rumex japonicus H.  

Hwang, Seon-Woo (Division of Applied Life Science, Gyeongsang National University)
Ha, Tae-Joung (Institute of Agriculture and Life Science, Gyeongsang National University)
Lee, Jong-Rok (Research Center of Biomedical Resources of Oriental Medicine, Daegu Haany University)
Lee, Jun (Division of Applied Life Science, Gyeongsang National University)
Nam, Sang-Hae (Dept. of Food Science, Chinju National University)
Park, Ki-Hun (Division of Applied Life Science, Gyeongsang National University)
Yang, Min-Suk (Division of Applied Life Science, Gyeongsang National University)
Publication Information
Applied Biological Chemistry / v.47, no.2, 2004 , pp. 274-278 More about this Journal
Abstract
Four anthraquinone derivatives were isolated from the root of Rumex japonicus Houtt. These compounds were identified as physcion, emodin, chrysophanol-10,10'-bianthrone and $physcion-10,10, respectively. The last compound (a), especially, showed strong activity against A549, PC-3, UO-31 and HCT-15 human cancer cell lines with $IC_{50}$ values, ranging from 0.45 to $1.33\;{\mu}g/ml^{-1})$.
Keywords
anthraquinone; bianthrone; emodin; physcion; cytotoxicity; Rumex japonicus HOUTT;
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