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http://dx.doi.org/10.11625/KJOA.2022.30.1.75

Effects of Natural Mineral Water on Reflux Esophagitis  

Choo, Byung-Kil (전북대학교 농업생명과학대학 작물생명과학과)
Publication Information
Korean Journal of Organic Agriculture / v.30, no.1, 2022 , pp. 75-87 More about this Journal
Abstract
Reflux esophagitis (RE) is a gastroesophageal reflux disease (GERD) caused by repeated reflux of gastric acid into the esophagus. The present study investigated the protective effect of natural mineral water on esophageal injury induced by gastric acid reflux. The cytotoxicity of mineral water was confirmed using Cell viability, proliferation and cytotoxicity assay kit. The protective effect of mineral water on esophageal injury was investigated in RE rat model. The results showed that no cytotoxicity of mineral water was observed in RAW264.7 cells. Mineral water decreased the ratio of esophageal damage, inhibited the increase of inflammatory-protein expression levels and increased the mucosa protection and tight junction proteins expression level in RE control rat. The results suggest that mineral water may have the potential to protect esophageal damage caused by gastric acid reflux and the potential to alleviate reflux esophagitis.
Keywords
anti-inflammation; natural mineral water; reflux esophagitis; tight junction;
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