Browse > Article
http://dx.doi.org/10.22424/jmsb.2019.37.3.155

Lactobacillus acidophilus as a Probiotics  

Oh, Sejong (College of Agriculture & Life Sciences, Chonnam National University)
Publication Information
Journal of Dairy Science and Biotechnology / v.37, no.3, 2019 , pp. 155-166 More about this Journal
Abstract
Bacteria from the genus Lactobacillus are important for the production of fermented food and dairy products, and as symbionts in human and animals. Lactobacillus acidophilus has widely been used in the production of yogurt, health foods, and even medicines. The efficacy of L. acidophilus has been proven with regards to the reduction of cholesterol, prevention and treatment of diarrhea, modulation of the immune system, suppression of cancer, etc. Using molecular biology tools, Lactobacillus acidophilus has now been reclassified into six species: L. acidophilus, L. amylovorus, L. crispatus, L gallinarium, L. gasseri, and L. johnsonii. Thus, since L. acidophilus has now been marked as a newly defined species, caution is advised when reading future publications regarding this bacterium. In this article, the results of the reclassification of L. acidophilus are mentioned after an analysis of its field inheritance was performed by my research team. Especially, L. amylovorus KU4 (formerly named as L. acidophilus KU4; KCCM 10975P) is a novel probiotic strain that is isolated from humans; it has the ability to reduce cholesterol. It has also been reported as a microorganism that effectively inhibits the growth of pathogenic E. coli. However, this Korean patent (No 10-1541280) refers to a strain obtained from calves; the origin of this strain was incorrectly labeled. Furthermore, after the discovery of L. acidophilus in 1900, its role in intestinal microbiological research was described and its utilization as a probiotic was presented.
Keywords
Lactobacillus acidophilus; probiotics; reclassification; lactic acid bacteria;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Weirich A, Hoffmann GF. Ernst Moro (1874-1951): a great pediatric career started at the rise of university-based pediatric research but was curtailed in the shadows of Nazi laws. Eur J Pediatr. 2005;164:599-606.   DOI
2 Weiss H. Zur Kentniss der Darmflora. Centralbl F Bakt Abt. 1904;1:13-28.
3 Pederson CS. The relationship between Lactobacillus acidophilus (Moro) Holland and Lactobacillus casei (Orla-Jensen) Holland. J Bacteriol. 1947;53:407-415.   DOI
4 Sneath PH, Mair NS, Sharpe ME, Holt JG. Bergey's manual of systematic bacteriology. Vol. 2. New York, NY: Williams & Wilkins; 1986.
5 Lewis SJ, Burmeister S. A double-blind placebo-controlled study of the effects of Lactobacillus acidophilus on plasma lipids. Eur J Clin Nutr. 2005;59:776-780.   DOI
6 Song M, Park S, Lee H, Min B, Jung S, Kim E, et al. Effect of Lactobacillus acidophilus NS1 on plasma cholesterol levels in diet-induced obese mice. J Dairy Sci. 2015;98:1492-1501.   DOI
7 Szajewska H, Ruszczynski M, Kolacek S. Meta-analysis shows limited evidence for using Lactobacillus acidophilus LB to treat acute gastroenteritis in children. Acta Paediatr. 2014;103:249-255.   DOI
8 Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand P. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009; 124: e172-e179.   DOI
9 Ishida Y, Nakamura F, Kanzato H, Sawada D, Hirata H, Nishimura A, et al. Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. J Dairy Sci. 2005;88:527-533.   DOI
10 Park SS, Lee YJ, Song S, Kim B, Kang H, Oh S, et al. Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver. J Endocrinol. 2018;237:87-100.   DOI
11 Fujisawa T, Benno Y, Yaeshima T, Mitsuoka T. Taxonomic study of the Lactobacillus acidophilus group, with recognition of Lactobacillus gallinarum sp. nov. and Lactobacillus johnsonii sp. nov. and synonymy of Lactobacillus acidophilus group A3 (Johnson et al. 1980) with the type strain of Lactobacillus amylovorus (Nakamura 1981). Int J Syst Evol Micr. 1992;42:487-491.
12 Du Plessis EM, Dicks LM. Evaluation of random amplified polymorphic DNA (RAPD)-PCR as a method to differentiate Lactobacillus acidophilus, Lactobacillus crispatus, Lactobacillus amylovorus, Lactobacillus gallinarum, Lactobacillus gasseri, and Lactobacillus johnsonii. Curr Microbiol. 1995;31:114-118.   DOI
13 Kim S. Bacteriocin produced by strains of Lactobacillus acidophilus isolated from different animal species. [Ph D. dissertation]. Deparment of Food Science, Oklahoma State University; 1992.
14 Oh S, Kim S, Worobo RW. Characterization and purification of a bacteriocin produced by Lactobacillus acidophilus 30SC: human isolate for potential use as a probiotic strains. J Dairy Sci. 2000;83:2747-2752.   DOI
15 Oh S, Kim Y, Kim S. Novel Lactobacillus sp. KU4 with probiotic activities. Korea Patent 2015;10-1541280.
16 Pridmore RD, Berger B, Desiere F, Vilanova D, Barretto C, Pittet AC, et al. The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proc Natl Acad Sci. 2004;101:2512-2517.   DOI
17 Jewell JB, Kashket ER. Osmotically regulated transport of proline by Lactobacillus acidophilus IFO 3532. Appl Environ Microbiol. 1991;57;2829-2833.   DOI
18 Vergio FV. Anti- und probiotika. Hippokrates. 1954;25:116-119.
19 Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, Reid G. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol. 2009;53:487-495.   DOI
20 Oh HK, Lee JY, Lim SJ, Kim MJ, Kim GB, Kim JH, et al. Molecular cloning and characterization of a bile salt hydrolase from Lactobacillus acidophilus PF01. J Microbiol Biotechnol. 2008;18:449-456.
21 Lilly DM, Stillwell RH. Probiotics: growth promoting factors produced by microorganisms. Science. 1965;147:747-748.   DOI
22 Parker RB. Probiotics, the other half of the antibiotic story. Anim Nutr Health. 1974;29:4-8.
23 Fuller R. Probiotics in man and animals. J Appl Bacteriol. 1989;66:365-378.   DOI
24 Salminen S, Ouwehand A, Benno Y, Lee YK. Probiotics: how should they be defined? Trends Food Sci Tech. 1999;10:107-110.   DOI
25 FAO/WHO. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Cordoba, Argentina: FAO/WHO; 2001.
26 FAO/WHO. Guidelines for the evaluation of probiotics in food. London, ON: FAO/WHO; 2002.
27 Escherich T. Die darmbakterien des neugeborenen und Sauglings. Fortschr Med. 1885;3:515-522.
28 Oh SJ. Probiotics and prolongation of life. J Milk Sci Biotechnol. 2008;26;31-37.
29 Oh S. A chronological review of Lactobacillus acidophilus. Food Sci Ind. 2014;47:8-13.
30 Bull M, Plummer S, Marchesi J, Mahenthiralingam E. The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiol Lett. 2013:349:77-87.   DOI
31 Tissier H. Recherches sur la flore du intestinale normale et pathologique du nourrison (e'tat normal et pathologique). Paris: G. Carre et C Naud; 1900. p. 85-96.
32 Moro E. Ueber den Bacillus acidophilus. Jahrb F Kinderh. 1900;52:38-55.
33 Billroth T. Untersuchungen uber die Vegetationsformen von Coccobacteria septica und den Antheil: welchen sie an der Entstehung und Verbreitung der accidentellen Wundkrankheiten haben. Versuch einer wissenschaftlichen Kritik der verschiedenen Methoden antiseptischer Wundbehandlung. Berlin: G Reimer; 1874. p. 244.
34 Cahn A. Ueber die nach Gram farbbaren Bacillen des Sauglingsstuhles. Centralbl F Bakt Orig. 1901;30:721-726.
35 Mac Neal WJ, Latzer LL, Kerr JE. The fecal bacteria of health men. J Inf Dis 1909;6:123-169.   DOI
36 Rettger LF, Cheplin HA. A treatise on the transformation of the interstinal flora with special reference to the implantation of Bacillus acidophilus. New Haven, CT: Yale University Press; 1921.
37 Rosner JL. Ten times more microbial cells than body cells in humans. Microbe. 2014;9:47.
38 Escherich T. Die Darmbakterien des sauglings und ihre beziehungen zur physiologie der verdauung. Stuttgart: Enke; 1886. p. 180.