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http://dx.doi.org/10.48022/mbl.2204.04003

Anti-Inflammatory Effect of Carex scabrifolia Steud. Extract in RAW264.7 Cells  

Joong Hyun Shim (Department of Cosmetic Science, Semyung University)
Publication Information
Microbiology and Biotechnology Letters / v.50, no.3, 2022 , pp. 354-360 More about this Journal
Abstract
This research was designed to evaluate the possible anti-inflammatory effects of Carex scabrifolia Steud. extract using RAW264.7 cells. The assessments of these effects were based on cell viability assay, mRNA expression levels of interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNFα), and levels of nitric oxide (NO)/prostaglandin E2 (PGE2) production. Quantitative real-time polymerase chain reaction showed that treatment with C. scabrifolia Steud. extract decreased the mRNA levels of iNOS, COX2, IL-1α, IL-1β, IL-6, and TNFα. Furthermore, from the production levels of PGE2/NO, it can be inferred that C. scabrifolia Steud. extract exhibited anti-inflammatory properties. These results suggest that C. scabrifolia Steud. extract contains anti-inflammatory compound(s), and consequently, that it may have applications as a potent cosmeceutical material.
Keywords
Carex scabrifolia Steud.; inflammation; iNOS; COX2; interleukins; TNF${\alpha}$;
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