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http://dx.doi.org/10.4014/mbl.1509.09001

Anti-inflammatory and Anti-tumor Effects of Tetragonia tetragonoides Extracts  

Choi, Hye Jung (Department of Biology and Chemistry, Changwon National University)
Yee, Sung-Tae (College of Pharmacy, Sunchon National University)
Kwon, Gi-Seok (Department of Bioresource Science, Andong National University)
Joo, Woo Hong (Department of Biology and Chemistry, Changwon National University)
Publication Information
Microbiology and Biotechnology Letters / v.43, no.4, 2015 , pp. 391-395 More about this Journal
Abstract
We examined the anti-inflammatory effect and anti-tumor activity of Tetragonia tetragonioides crude extracts and fractions. The anti-inflammatory activity of T. tetragonioides was exuded through the inhibition of lipopolysaccharide (LPS, $1{\mu}g/ml$), induced nitric oxide (NO) and interleukin (IL)-$1{\beta}$ production. The production of IL-6 and tumor necrosis factor $(TNF)-{\alpha}$ also decreased in LPS induced RAW264.7 cells after treatment with polysaccharide (PS) fraction. Furthermore, the hexane (HX) fraction strongly inhibited the granulocytes macrophage-colony stimulating factor (GM-CSF) production. In ICR mice previously inoculated with Sarcoma 180, the life prolongation effects were 16.67% with an intraperitoneal injection of methanol (MeOH) extract and polysaccharide fraction at a dose of 100 mg/kg/day. The results are an important preliminary step toward the development of effective anti-inflammatory and anti-tumor agents using T. tetragonioides.
Keywords
Anti-inflammatory; anti-tumor; RAW264.7 cells; ICR mice; Tetragonia tetragonioides;
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