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http://dx.doi.org/10.4014/mbl.1507.07008

Anti-Oxidative and Anti-Inflammatory Activities of Cotoneaster horizontalis Decne Extract  

Lee, Ji Young (Blue-Bio Industry Regional Innovation Center, College of Natural Science &Human Ecology, Dong-Eui University)
Jin, Kyong-Suk (Blue-Bio Industry Regional Innovation Center, College of Natural Science &Human Ecology, Dong-Eui University)
Kwon, Hyun Ju (Blue-Bio Industry Regional Innovation Center, College of Natural Science &Human Ecology, Dong-Eui University)
Kim, Byung Woo (Blue-Bio Industry Regional Innovation Center, College of Natural Science &Human Ecology, Dong-Eui University)
Publication Information
Microbiology and Biotechnology Letters / v.43, no.3, 2015 , pp. 280-285 More about this Journal
Abstract
Anti-oxidative and anti-inflammatory activities of Cotoneaster horizontalis Decne ethanol extract (CHEE) were evaluated. CHEE possessed a potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl, which was similar to the activity of ascorbic acid which was used as a positive control. CHEE also effectively suppressed hydrogen peroxide-induced reactive oxygen species on RAW 264.7 cells. Furthermore, CHEE induced the expression of the anti-oxidative enzyme heme oxygenase 1, and its upstream transcription factor, nuclear factor-E2-related factor 2. CHEE inhibited LPS induced nitric oxide (NO) formation as a consequence of inducible NO synthase (iNOS) down regulation. Taken together, these results provide us with an important new insight; that C. horizontalis possesses anti-oxidative and anti-inflammatory activities. Therefore, C. horizontalis may be utilized as a promising material in the field of nutraceuticals.
Keywords
Cotoneaster horizontalis; anti-oxidative; anti-inflammatory;
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