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http://dx.doi.org/10.4014/kjmb.1405.05006

In-vitro Anti-thrombosis Activity of Ehwa Nuruk  

Kim, Mi-Sun (Department of Food and Nutrition, Andong National University)
Lee, Ye-Seul (Department of Food and Nutrition, Andong National University)
Kim, Jong Sik (Department of Life Science, Andong National University)
Shin, Woo-Chang (Research Institute, Kooksoondang Brewery Co. Ltd.)
Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
Publication Information
Microbiology and Biotechnology Letters / v.42, no.3, 2014 , pp. 302-306 More about this Journal
Abstract
Ehwa nuruk (EN), a traditional Korean alcoholic rice beverage, is manufactured from pulverized wet rice and the needles of pine trees. In this study, the ethanol extract of EN and its subsequent organic solvent fractions were prepared, and their in-vitro anti-thrombosis activity evaluated. In an anti-coagulation assay, only the ethylacetate (EA) fraction of the ethanol extract showed significant extensions of thrombin time, prothrombin time and activated partial thromboplastin time. In a platelet aggregation assay, the water residue of the ethanol extract exhibited aggregation inhibitory activity. Our results suggest that the EA fraction has potential as a new anticoagulation agent and EN could be used as a novel resource for anti-thrombosis agents. This report provides the first evidence of the anti-thrombosis activity of EN.
Keywords
Anti-coagulation; anti-platelet aggregation; ehwa nuruk;
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Times Cited By KSCI : 12  (Citation Analysis)
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