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http://dx.doi.org/10.4014/kjmb.1407.07006

Effect of Ionic Liquid on Increased Surface Area Crystallization Process for Vancomycin  

Kim, Sung-Jae (Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
Microbiology and Biotechnology Letters / v.42, no.3, 2014 , pp. 297-301 More about this Journal
Abstract
We examined the effect of ionic liquid on the crystallization efficiency of vancomycin in an increased surface area crystallization with silica gel. The crystallization efficiency was improved by the addition of ionic liquid, [BMIm][$BF_4$]. The addition of ionic liquid (20%, v/v) on the increased surface area crystallization with silica gel dramatically reduced the crystallization time by 6 folds (4 h), compared with the results of the case where the surface area-increasing material and ionic liquid had not been added. In addition, the crystal size of vancomycin was decreased and the crystal quality of vancomycin was improved by increasing the addition of ionic liquid.
Keywords
Vancomycin; increased surface area crystallization; silica gel; ionic liquid;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
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1 Kim WS, Lee EK. 2005. Technological trend of crystallization research for bioproduct separation. Korean J. Biotechnol. Bioeng. 20: 164-176.
2 Kim YN, Lee JY, Kim JH. 2011. Improvement of a crystallization process for the purification of vancomycin. Process Biochem. 46: 2068-2073.   DOI
3 Kroon MC, Toussaint VA, Shariati A, Florusse LJ, Spronsen JV, Witkamp GJ, et al. 2008. Crystallization of an organic compound from an ionic liquid using carbon dioxide as antisolvent. Green Chem. 10: 333-336.   DOI
4 Kwak EA, Kim SJ, Kim JH. 2012. Effect of ion exchange resin on increased surface area crystallization process for purification of vancomycin. Korean J. Chem. Eng. 29: 1487-1492.   DOI
5 Lee JW, Jung YT, Suh JW, Lee KS. 2006. Process of purifying vancomycin hydrochloride. U.S. Patent 7,018,814.
6 Pusey ML, Paley MS, Turner MB, Rogers RD. 2007. Protein crystallization using room temperature ionic liquids. Cryst. Growth Des. 7: 787-793.   DOI   ScienceOn
7 Lee JY, Lee KH, Chae HJ, Kim JH. 2010. Systematic evaluation and optimization of crystallization conditions for vancomycin purification. Korean J. Chem. Eng. 27: 1538-1546.   DOI
8 Li XX, Xu XD, Dan YY, Feng J, Ge L, Zhang ML. 2008. The crystallization of lysozyme in the system of ionic liquid [BMIm][BF4]-water. Crystallogr. Rep. 43: 1062-1068.
9 Li XX, Xu XD, Dan YY, Zhang ML. 2009. The Crystallization of lysozyme and thaumatin with ionic liquid. Crystallogr. Rep. 54: 1285-1288.   DOI
10 United States Pharmacopoeia (USP 29): Vancomycin hydrochloride, United State Pharmacopeial Convention, Inc. 2006.
11 Wang Z, Fang W, Li Y, Zhang J, Gu Q. 2014. A new strategy for protein crystallization: Effect of ionic liquids on lysozyme crystallization and morphology. Korean J. Chem. Eng. 31: 919-923.   DOI
12 Judge RA, Takahashi S, Longenecker KL, Fry EH, Abad-Zapatero C, Chi ML. 2009. The effect of ionic liquids on protein crystallization and X-ray diffraction resolution. Cryst. Growth Des. 9: 3463-3469.   DOI   ScienceOn
13 Griffith RS. 1984. Vancomycin use-an historical review. J. Antimicrob. Chemother. 14: 1-5.
14 Hebel D, Urdingen M, Hekmat D, Weuster-Botz D. 2013. Development and scale up of high-yield crystallization processes of lysozyme and lipase using additives. Cryst. Growth Des. 13: 2499-2506.   DOI
15 Kim KJ. 2001. Crystallization process and technology. Prospect. Ind. Chem. 4: 1-15.
16 Kim SI, Han CY, Jung HS, Lee JS, Ok SY, Kim SC. 2006. Effects of vancomycin on the neuromuscular blockade of vecuronium, rocuronium and atracurium in rat phrenic nervehemidiaphragm preparation. Korean J. Anesthesiol. 51: 727-732.   DOI
17 Yan H, Qi D, Cheng X, Song Z, Li W, He B. 1998. Antibiotic activities and affinities for bacterial cell wall analogue of N-demethylvancomycin and its derivatives. J. Antibiot. 51: 750-756.   DOI