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Characteristics of immunomodulation by a Lactobacillus sakei proBio65 isolated from Kimchi  

Lim, Jeong-Heui (Department of Applied Microbiology and Biotechnology, Yeungnam University)
Seo, Byoung-Joo (Department of Applied Microbiology and Biotechnology, Yeungnam University)
Kim, Jung-Eun (School of Life Sciences, Gwangju Institute of Science and Technology)
Chae, Chang-Suk (School of Life Sciences, Gwangju Institute of Science and Technology)
Im, Sin-Hyeog (Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University)
Hahn, Youn-Soo (Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University)
Park, Yong-Ha (Department of Applied Microbiology and Biotechnology, Yeungnam University)
Publication Information
Microbiology and Biotechnology Letters / v.39, no.3, 2011 , pp. 313-316 More about this Journal
Abstract
We isolated and identified a novel probiotic strain, Lactobacillus sakei proBio65 from Kimchi. To determine whether L. sakei proBio65 has an immunomodulatory effect, we investigated cells via an in vitro screening system which co-cultured freshly isolated mesenteric lymphocyte with probiotics. A significant increase of $Foxp3^+$ transcription regulatory factor expression was observed, followed by an increase in anti-inflammatory cytokines transcription regulatory factor. L. sakei proBio65 exhibited high levels of the IL-10/IL-12 production ratio and enhanced Foxp3 expression in vitro. L. sakei proBio65 may thus be therapeutically useful for the modulation of inflammatory immune disorders.
Keywords
Lactobacillus sakei proBio65; regulatory T cell; anti-inflammation; interleukin-10; interleukin-12;
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